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Biore Sunscreen Uk

2017 Biore UV Aqua Rich Watery Essence Sunscreen Made in Japan 50g SPF50+ PA++++ | eBay

2017 Biore UV Aqua Rich Watery Essence Sunscreen Made in Japan 50g SPF50+ PA++++ | eBay


eBay

2017 Biore UV Aqua Rich Watery Essence Sunscreen Made in Japan 50g SPF50+ PA++++ | Health & Beauty, Sun Care & Tanning, Sunscreens & Sunblocks | eBay!

Biore UV Aqua Rich Watery Essence Sunscreen SPF50+ PA+++ reviews, photos, ingredients

Biore UV Aqua Rich Watery Essence Sunscreen SPF50+ PA+++ reviews, photos, ingredients


MakeupAlley

Biore UV Aqua Rich Watery Essence Sunscreen SPF50+ PA+++: rated 4.2 out of 5 on MakeupAlley. See 192 member reviews, ingredients and photos.

Melanin Maintenance: The Best Sunscreen For Brown Skin

Melanin Maintenance: The Best Sunscreen For Brown Skin


MadameNoire

Sunscreen protects your skin from sun damage, and many of the sunscreens on this list also reduce the appearance of discoloration and hyperpigmentation.

Adjusting Neutrophil Behavior to Enhance Stroke Recovery

by @ LongeCityNews

An emerging theme in regenerative research is the importance of the innate immune system to the mechanisms of tissue maintenance, and researchers have so far found a number of ways in which the behavior of these immune cells might potentially be adjusted in order to enhance healing. The scientific community has made initial strides with macrophages and microglia, shifting the balance of pro-inflammatory versus pro-regenerative cells, and here some of the same high level themes are observed in the response to injury of the innate immune cells known as neutrophils. It matters greatly as to whether these immune cells turn up at the point of injury in the mode of defending against intruding pathogens, or in the mode of assisting with repair; they are capable of both, but individual cells tend to be focused only on one of these at a given time.

White blood cells called neutrophils are like soldiers in your body that form in the bone marrow and at the first sign of microbial attack, head for the site of injury just as fast as they can to neutralize invading bacteria or fungi using an armament of chemical weapons. But when that injury is an intracerebral hemorrhage, which releases blood into the brain, neutrophils arrive at the point of battle only to discover that there's no infection to attack. Unless immediately removed from the brain by other immune cells, they actually cause damage and deploy an array of toxic chemicals into the brain that worsen injury.

Now researchers have discovered a way to temporarily suppress these soldiers' pro-killing effect and turn them into beneficial weapons that scavenge for toxins, potentially opening a door for a therapeutic approach to hemorrhagic stroke treatment. A hemorrhagic stroke occurs when an artery inside the brain leaks or ruptures. It is the second-most common form of stroke after ischemic stroke, has a 30 to 67 percent mortality rate and is the main cause of disabilities among adults. Because half of hemorrhagic stroke victims die within the first two days, researchers believe that deadly secondary damage, including through toxicity of iron from the breakdown of red blood cells, leads to an excess in free radicals and inflammation.

Along with carrying chemicals that could aggravate injury, neutrophils produce and release potentially beneficial molecules including lactoferrin, an iron-binding protein. At the same time the neutrophils are getting ready to attack inside the brain, the brain and spleen are releasing interleukin-27 molecules, which can signal to the neutrophils to produce more lactoferrin and thus benefit the brain as it recovers from the stroke injury. "This is one of the first discoveries showing that you can train neutrophils to act as friendly cells. We've adapted how the body already responds naturally, but it can take 12 to 18 hours for the signal to turn them from damaging neutrophils to the beneficial cells that release lactoferrin and by then, it can be too late. Treatment with lactoferrin in our models is effective in reducing brain damage after hemorrhage and we are working on a modified form of lactoferrin that could penetrate the brain better and quicker."

Link: https://www.uth.edu/media/story.htm?id=caf2ac24-bf5a-433e-aa00-e0d22ba0209b


View the full article at FightAging

List of Sunscreens That Will Prevent Sunscreen Stains on Clothes - Mama's Laundry Talk

List of Sunscreens That Will Prevent Sunscreen Stains on Clothes - Mama's Laundry Talk


Mama's Laundry Talk

The sunscreens on the list will prevent sunscreen stains on clothes!

UK STOCK Biore UV Aqua Rich Watery Essence Water Base SunScreen SPF50+/PA++++ | eBay

UK STOCK Biore UV Aqua Rich Watery Essence Water Base SunScreen SPF50+/PA++++ | eBay


eBay

UK STOCK Biore UV Aqua Rich Watery Essence Water Base SunScreen SPF50+/PA++++ | Belleza y salud, Bronceado y protección solar, Protectores solares | eBay!

2017 Biore UV Aqua Rich Watery Essence Sunscreen Made in Japan 50g SPF50+ PA++++  | eBay

2017 Biore UV Aqua Rich Watery Essence Sunscreen Made in Japan 50g SPF50+ PA++++ | eBay


eBay

Kao Biore UV Aqua Rich Watery Essence Sunscreen. Authentic Product, Made in Japan for Japanese Market. made in Japan for sale to the Japanese market (. not cheaper versions made in or made for China/Taiwan). | eBay!

New 2 x Biore UV Sunscreen Perfect Face Milk Waterproof Sweatproof SPF50+ PA++++ • $19.00

New 2 x Biore UV Sunscreen Perfect Face Milk Waterproof Sweatproof SPF50+ PA++++ • $19.00


PicClick

New 2 x Biore UV Sunscreen Perfect Face Milk Waterproof Sweatproof SPF50+ PA++++ FOR SALE • $19.00 • See Photos! Money Back Guarantee. New 2 x Biore UV Sunscreen Perfect Face Milk Waterproof Sweatproof SPF50+ PA++++ 30ml Biore UV Perfect Face Milk is ultra light, smooth and milky in texture with moisturizing ingredients 262626240296

Cruelty-Free Sunscreens to Soak Up the Sun

Cruelty-Free Sunscreens to Soak Up the Sun


PETA

We've done all the research for you—here are our top five cruelty-free sunscreens for your sunny summer days!

LongeCity Affiliate Labs

by @ Articles

The Longecity “Affiliate Labs” are small, research-focused enterprises or independent academic research groups led by a scientists with strong ties to the Longecity community and a proven track record of commitment to scientific inquiry directly relevant to the Longecity mission.
These leaders and their colleagues are not just trailblazers in advancing important areas of regenerative and rejuvenation research, but also incredibly helpful when there is a community need for peer review, when providing advice and training to a young scientist, and in providing the expertise and tools to test the novel, controversial, or promising scientific leads sourced from the Longecity community and beyond.

Community Funding
There is a small support fund that the labs can draw on to flexibly support their research activities. While not a substitute for private investment and public sector grants, the ability to flexibly ‘just try’ out a new idea without needing to ‘pitch’ in lengthy proposals can be an invaluable accelerator to research progress. All Affiliates have an active link to the Longecity community, so there is a level of accountability and responsiveness beyond anything encountered in ‘traditional’ research donations.
By donating to the Affiliate Labs fund, Members can be assured that every penny goes directly to an expert personally and professionally committed to making a difference in the scientific conquest of death.
Donate HERE

Current Affiliate Labs
- Alexandra Stolzing, Loughborough University, UK & Leipzig University, Germany.
- João Pedro de Magalhães, University of Liverpool, UK
- Kelsey Moody, Ichor Therapeutics, USA.
- Kevin Perrott – Buck Institute, USA
- Matthew O’Connor – SENS Foundation, USA

Nearly Half of U.S. Sunscreens Would Be Banned in Europe. Why? They Don't Work

Nearly Half of U.S. Sunscreens Would Be Banned in Europe. Why? They Don't Work


Dr. Axe

And about 14% of sunscreens on the market contain an ingredient that actually triggers skin cancer lesions and tumors!

Sunscreen showdown 2K16: Review of Biore, Missha, TonyMoly, Sunbears and Holika Holika Sunscreens

Sunscreen showdown 2K16: Review of Biore, Missha, TonyMoly, Sunbears and Holika Holika Sunscreens


Peepingpomeranian

Followers on my Instagram (@peepingpomeranian) and Snapchat (@peepingpompom) have already seen some of the testing and peeks at how the different sunscreens in my collection fared. But for the rest…

Sunscreens For Rosacea Sensitive Skin - Talonted Lex

Sunscreens For Rosacea Sensitive Skin - Talonted Lex


talonted lex

Sunscreens For Rosacea Sensitive Skin - It's tricky to find a sunscreen that works but won't aggravate my reactive skin. Hear my 7 recommendations here.

Products for Fair Skin | Chanel UV ESSENTIEL Daily Multi-Protection Facial Sunscreen SPF50+ ⋆ Forever Amber | UK fashion, lifestyle and pregnancy blog

Products for Fair Skin | Chanel UV ESSENTIEL Daily Multi-Protection Facial Sunscreen SPF50+ ⋆ Forever Amber | UK fashion, lifestyle and pregnancy blog


Forever Amber | UK fashion, lifestyle and pregnancy blog

A few weeks ago I talked a bit about how a good sunscreen is worth its weight in gold (which is almost how much this one cost, funnily enough!), so today I thought I'd show you the product I'm using at the moment, which is Chanel's UV Essentiel Daily UV Care in SPF50+. Now, it would be wrong of m

Why do some turtles outlive humans?

by @ Articles

(⇒ write for LongeCity )


The oldest human recorded in modernity was Jeanne Louise Calment, she died in the age of 122 years and 164 days [1] .

There are rumors that the oldest tortoise called Adwaita (Aldabra giant tortoise) died in the age of about 250 years [2] or that it was 188-year-old radiated tortoise named Tui Malila [3] , or that the highest verified age of 177 years had Galapagos giant tortoise Harriet [4] . The oldest currently living turtle is considered to be Jonathan (Seychelles giant tortoise), estimated to be over 180 years old these days [5] . Although all aforementioned numbers are estimations, it seems these turtles were older than human supercentenarians.

All previously mentioned species are terrestrial tortoises, a group with longest lifespans among turtles. The most famous of them, well-researched Galapagos giant tortoise, was observed by Charles Darwin when he was forming his well-known theory of evolution by natural selection [6] . There is only one freshwater turtle known to be able to outlive human, it is the common snapping turtle estimated to live up to more than hundred years [7] . While being considerably less researched, recorded maximal lifespan of sea turtles is usually shorter, not exceeding 80 years, however, it is believed that the green sea turtle can live up to 100 years. [8]

It is a difficult question to answer why these reptiles can outlive us because even to determine the actual age of animals with a long lifespan is complicated – partially due to the fact that it takes such a long time to study. Furthermore, many turtles are endangered species [9] so there may not be as many organisms to hand as needed for proper statistics. Nonetheless, we can still claim that turtles are among the most long-living vertebrates on earth [10] . Why?

Firstly, turtles, like all reptiles, benefit from being ectothermic organisms. They do not maintain body temperature and thus save a lot of energy. But that also means they are less flexible: it is crucial for their lifespan to be in natural temperature environment of daily cycles with night-time temperature drop [11] . If they do not live under these conditions in captivity, metabolic pathways change and turtles die much sooner. [12]

Turtles are well-adapted in other ways: their famous shell – the carapace –is good protection against natural predators. Most of hatchling turtles with a soft shell do not survive the first year [13] . A research of natural populations of freshwater turtles showed that only one per cent of them can celebrate the twentieth birthdays, but once the adulthood is reached, mortality rate drops and remains constant throughout the rest of life [14] .

Some turtles can survive under extreme environmental conditions, such as freezing [15] or lack of oxygen for months [16] . They can even undergo hibernation and anaerobic metabolism and therefore deal with hypoxia and anoxia, it was also proposed that the same genes can play a role in longevity itself [17] and also in oxidative stress resistance [18] that further promotes longer life [19] .

Turtle’s bones and shell are used as lactate buffer lowering metabolic acidosis caused by anaerobic glycolysis during the period of lack of oxygen [20] ; [21] Their organism is protected by strong innate immunity compensating slow acquired immune reactions [22] .

Because turtles have very slow metabolism as well as growth, their bodies do not need to deal with excessive metabolic heat and byproducts as mammals [23] . Their natural diet is very simple but also necessary for their longevity. [24]

According to the evolutionary theories, staying alive is less important after menopause. Galapagos giant tortoises achieve sexual maturity late (around the age of up to forty years in the wild, and between twenty and twenty-five years of life in captivity [25] ), then staying fertile until death [26] .

The Hayflick limit is said to determine how many times a cell can divide [27] . The Hayflick limit of Galapagos giant tortoise was said to be about 110 divisions [28] , approximately twice as many as 50 of human cells [29] . Studies in this context have highlighted the importance of telomeres, the protective end sequences of chromosomes, that get shorter with each cell division [30] , can play at least a partially role in life expectancy. It was observed that telomeres in European freshwater turtle’s cells are of the same length in both embryo and adult organism [31] .

Thus, it was believed that turtles are negligibly senescent organisms [32] . In other words, the cells do not age and no age-related diseases appear, which is very different cell behavior than in human bodies [33] and probably the key to any natural longevity. However, evidence now suggests that turtles may not be really negligibly senescent because of observations of survival and reproductive senescence in late age in the painted turtle population [34]

As we can see, turtles have some advantages in the lifespan field. Some of these might inspire researchers to increase lifespans in humans.



References

[1] Oldest person ever. Retrieved January 31, 2017, from http://www.guinnessworldrecords.com/world-records/oldest-person
[2] BBC (2006, March 23). “Clive of India’s” tortoise dies. BBC South Asia. Retrieved from http://news.bbc.co.uk/2/hi/south_asia/4837988.stm
[3] Associated Press (2006, June 26). Tortoise believed to have been owned by Darwin Dies at 176. Fox News. Retrieved from http://www.foxnews.com/story/2006/06/26/tortoise-believed-to-have-been-owned-by-darwin-dies-at-176.html
[4] Galapagos tortoise (Geochelone nigra) longevity, ageing, and life history. Retrieved January 31, 2017, from http://genomics.senescence.info/species/entry.php?species=Geochelone_nigra
[5] Hollins, J. (2012). The world’s most isolated vet? Veterinary Record, 171(2), i–i. doi:10.1136/vr.g7292
[6] Powell, J., & Caccone, A. (2006). Giant tortoises. Current Biology, 16(5), R144–R145. doi:10.1016/j.cub.2006.02.050
[7] Cameron, M. (2008). COSEWIC Assessment and Status Report on the Snapping Turtle Chelydra serpentina in Canada . Retrieved from http://publications.gc.ca/collections/collection_2009/ec/CW69-14-565-2009E.pdf
[8] Green sea turtle (Chelonia mydas) longevity, ageing, and life history. Retrieved January 31, 2017, from http://genomics.senescence.info/species/entry.php?species=Chelonia_mydas
[9] Jacobson, E. R. (1994). Causes of Mortality and Diseases in Tortoises: A Review. Journal of Zoo and Wildlife Medicine, 25(1), 2–17.
[10] Gibbons, J. W. (1987). Why do turtles live so long? BioScience, 37(4), 262–269. doi:10.2307/1310589
[11] Flouris, A. D., & Piantoni, C. (2014). Links between thermoregulation and aging in endotherms and ectotherms. Temperature, 2(1), 73–85. doi:10.4161/23328940.2014.989793
[12] Vadala, N. How Long Do Turtles Live? Retrieved January 31, 2017, from http://www.petmd.com/reptile/care/how-long-do-turtles-live
[13] Stewart, K. R., & Wyneken, J. (2004). Predation risk to loggerhead hatchlings at a high-density nesting beach in Southeast Florida. Bulletin of Marine Science, 74(2), 325–335.
[14] Gibbons, J. W., & Semlitsch, R. D. (1982). Survivorship and longevity of a long-lived vertebrate species: How long do turtles live? The Journal of Animal Ecology, 51(2), 523. doi:10.2307/3981
[15] Packard, G. C., & Packard, M. J. (2003). Natural freeze-tolerance in hatchling painted turtles? Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 134(2), 233–246. doi:10.1016/s1095-6433(02)00264-7
[16] Milton, S. L., & Prentice, H. M. (2007). Beyond anoxia: The physiology of metabolic downregulation and recovery in the anoxia-tolerant turtle. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 147(2), 277–290. doi:10.1016/j.cbpa.2006.08.041
[17] Shaffer, H. B., Minx, P., Warren, D. E., Shedlock, A. M., Thomson, R. C., Valenzuela, N., … Wilson, R. K. (2013). The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage. Genome Biology, 14(3), R28.doi:10.1186/gb-2013-14-3-r28
[18] Garbarino, V. R., Orr, M. E., Rodriguez, K. A., & Buffenstein, R. (2015). Mechanisms of oxidative stress resistance in the brain: Lessons learned from hypoxia tolerant extremophilic vertebrates. Archives of Biochemistry and Biophysics, 576, 8–16. doi:10.1016/j.abb.2015.01.029
[19] von Zglinicki, T. (2002). Oxidative stress shortens telomeres. Trends in Biochemical Sciences, 27(7), 339–344. doi:10.1016/s0968-0004(02)02110-2
[20] Jackson, D. C. (2000). Living without oxygen: Lessons from the freshwater turtle. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 125(3), 299–315. doi:10.1016/s1095-6433(00)00160-4
[21] Krivoruchko & Storey, 2010).
[22] Sandmeier, F. C., Tracy, C. R., Dupre, S., & Hunter, K. (2012). A trade-off between natural and acquired antibody production in a reptile: Implications for long-term resistance to disease. Biology Open, 1(11), 1078–1082. doi:10.1242/bio.20122527
[23] Bilinski, T., Paszkiewicz, T., & Zadrag-Tecza, R. (2015). Energy excess is the main cause of accelerated aging of mammals. Oncotarget, 6(15), 12909–12919. doi:10.18632/oncotarget.4271
[24] Casares, M., Honegger, R. E., & Rubel, A. (1995). Management of giant tortoises Geochelone elephantopus and Geochelone gigantean at Zurich Zoological gardens. International Zoo Yearbook, 34(1), 135–143. doi:10.1111/j.1748-1090.1995.tb00671.x
[25] Global, S. D. Z. (2010). Galapagos tortoise fact sheet. Retrieved January 31, 2017, from http://library.sandiegozoo.org/factsheets/galapagos_tortoise/tortoise.htm
[26] Curtin, A. J., Zug, G. R., & Spotila, J. R. (2009). Longevity and growth strategies of the desert tortoise (Gopherus agassizii) in two American deserts. Journal of Arid Environments, 73(4-5), 463–471. doi:10.1016/j.jaridenv.2008.11.011
[27] Hayflick, L. (1965). The limited in vitro lifetime of human diploid cell strains. Experimental Cell Research, 37(3), 614–636. doi:10.1016/0014-4827(65)90211-9
[28] Goldstein, S. (1974). Aging in vitro. Experimental Cell Research, 83(2), 297–302. doi:10.1016/0014-4827(74)90342-5
[29] Hayflick, L., & Moorhead, P. S. (1961). The serial cultivation of human diploid cell strains. Experimental Cell Research, 25(3), 585–621. doi:10.1016/0014-4827(61)90192-6
[30] Harley, C. B., Futcher, A. B., & Greider, C. W. (1990). Telomeres shorten during ageing of human fibroblasts. Nature, 345(6274), 458–460. doi:10.1038/345458a0
[31] Girondot, M., & Garcia, J. (1999). Senescence and longevity in turtles: What telomeres tell us. 9th extraordinary meeting of the societas Europaea Herpetologica, 1, 25–29. Retrieved from //www.researchgate.net/publication/252290006_Senescence_and_longevity_in_turtles_What_telomeres_tell_us
[32] Miller, J. K. (2001). Escaping senescence: Demographic data from the three-toed box turtle (Terrapene carolina triunguis). Experimental Gerontology, 36(4-6), 829–832. doi:10.1016/s0531-5565(00)00243-6
[33] Schächter, F., Cohen, D., & Kirkwood, T. (1993). Prospects for the genetics of human longevity. Human Genetics, 91(6), . doi:10.1007/bf00205074
[34] Warner, D. A., Miller, D. A. W., Bronikowski, A. M., & Janzen, F. J. (2016). Decades of field data reveal that turtles senesce in the wild. Proceedings of the National Academy of Sciences, 113(23), 6502–6507. doi:10.1073/pnas.1600035113

Review: Sofina Beauté UV Cut Emulsion NS SPF50 PA++++ (Fresh)

by Kerry @ Skin & Tonics : A Skincare Blog

It’s not a secret that I enjoy splurging on pricy skincare products – luxury skincare is one of my absolute favorite ways to treat myself. But sunscreen, which is the product I consider to be the most important product in my daytime skincare routine, is one product I actually don’t splurge on. To a non-regular-sunscreen-wearer, […]

The post Review: Sofina Beauté UV Cut Emulsion NS SPF50 PA++++ (Fresh) appeared first on Skin & Tonics : A Skincare Blog.

Beauty: the best lightweight facial sunblocks | Sali Hughes

Beauty: the best lightweight facial sunblocks | Sali Hughes


the Guardian

These days, we’re spoiled for choice

Kao Singapore finds creative ways to promote sunscreen

Kao Singapore finds creative ways to promote sunscreen


Marketing Interactive

The campaign is created with the help of Hakuhodo Singapore and IPG Mediabrands.

The Best Sunscreens for Not Feeling Like a Greased Sausage

The Best Sunscreens for Not Feeling Like a Greased Sausage


GQ

The best sunscreen is from Japan—featuring a water-weight, scentless formula that disappears on skin as if you weren’t wearing anything in the first place.

 Deep Pore Charcoal Cleanser | Ulta Beauty

Deep Pore Charcoal Cleanser | Ulta Beauty


ULTA Beauty

Biore Deep Pore Charcoal Cleanser draws out and traps 2x more dirt & impurities than a basic cleanser, purifying pores to leave your face deeply cleaned and your skin tingly-smooth.

My Favourite Japanese Sunscreens - Beautyholics Anonymous

My Favourite Japanese Sunscreens - Beautyholics Anonymous


Beautyholics Anonymous

© narstudio What’s the most important item in your skincare routine? Eye cream? Serum? Moisturiser? For me, it isn’t any of these. It’s sunscreen. I didn’t start wearing sunscreen regularly until I was in my early twenties. I know I should have started a lot earlier but when the only sunscreens I could get were …

List of Sunscreens That Will Prevent Sunscreen Stains on Clothes

by Lauren Hill @ Mama's Laundry Talk

As we head into summertime, many of us are diligently applying sunscreen to prevent sunburn. I have very fair skin, so I am definitely a faithful sunscreen user! Did you know that sunscreens that contain the ingredient avobenzone can produce stains on your clothes? If you’ve ever applied sunscreen to your head, face, neck, or […]

The post List of Sunscreens That Will Prevent Sunscreen Stains on Clothes appeared first on Mama's Laundry Talk.

Review: The Body Shop Skin Defence Multi Protection Essence sunscreen

Review: The Body Shop Skin Defence Multi Protection Essence sunscreen


My Women Stuff

Review of The Body Shop Skin Defence sunscreen that is lightweight and non-greasy but there is something about it that just doesn't work for me

I Used Only Vegan Make-Up For A Week And This Is What Happened

I Used Only Vegan Make-Up For A Week And This Is What Happened


InStyle.co.uk

Like most things in my life, it started with food. I’ve followed a vegetarian diet since I was 6 years old, and ditched animal products from my wardrobe...

Best Cruelty-Free Sunscreens No Matter Your Budget

Best Cruelty-Free Sunscreens No Matter Your Budget


Cruelty-Free Kitty

Sunscreen should be an essential part of every person's skincare regimen. Here are my top 5 picks for the best cruelty-free sunscreens, for every budget.

Review: The New 2015 Biore UV Aqua Rich Watery Essence SPF 50+ PA++++!!!!

Review: The New 2015 Biore UV Aqua Rich Watery Essence SPF 50+ PA++++!!!!


Fifty Shades of Snail

Guys, I have an announcement. I’m engaged! Yes, that’s right. The new 2015 Biore UV Aqua Rich Watery Essence sunscreen and I plan to elope soon. We will make our lifelong commit to each…

Review: Biore UV Aqua Rich Watery Essence Face Sunscreen SPF 50/ PA+++

Review: Biore UV Aqua Rich Watery Essence Face Sunscreen SPF 50/ PA+++


Skin & Tonics : A Skincare Blog

The first time I used Biore UV Aqua Rich Watery Essence Sunscreen, my immediate thought was, “Oh good, the perfect sunscreen! Sunscreen chemists, you can all go home now. Nice job, everyone!” Then …

Supplement Use and Analytics Made Simple (and Free)

by @ ImmInst Active Topics

Hi - I made this analytics engine and posted it here about two months back. The reaction was lukewarm, so I took it as I should refine it better. I took all the feedback I got from online communities and added a bunch of new features during that time. I'd love to show it off again! If you already saw it before, here's what new since then
 
- rolling correlated aggregations. IE. Want to see how a week of taking piracetam compares with a week without taking piracetam? Now you can!
- automatic sleep correlations
- fitbit integration
- better exporting of all your data (I made a promise to not hold any data hostage)
- an electronic calendar that lets you select any day and see what supplements you took during that day. So imagine three months from now, you want to know what you took on 9/22? Now you can with exact timestamps.
 
https://imgur.com/a/jXyhJ - An imgur album showing you the features
 
the link is @ https://betterself.io
 
Would love any feedback again.
 
Thanks!
Jeff

Global Sunscreen Market Size, Share, Growth, Trends, Industry Analysis and Forecast 2017 By Acute Market Reports

Global Sunscreen Market Size, Share, Growth, Trends, Industry Analysis and Forecast 2017 By Acute Market Reports


Mynewsdesk

Market Segment by Countries, this report splits Europe into several key Countries, with sales (consumption), revenue, market share and growth rate of...

[973403] KAO BIORE UV PERFECT SPRAY SUNCREEN 50G SPF50+ PA++++ JAPAN  | eBay

[973403] KAO BIORE UV PERFECT SPRAY SUNCREEN 50G SPF50+ PA++++ JAPAN | eBay


eBay

Features: Spray type suncreen. Very strong SPF50 , PA . For face & body, even hair and scalp. Introduce the new biore sunscreen spray type. It is fast and easy to apply. Very convenient to re-apply. | eBay!

Sunscreen Review 1: Cetaphil, Elucent, Alpha-H, Sunsense - Lab Muffin Beauty Science

Sunscreen Review 1: Cetaphil, Elucent, Alpha-H, Sunsense - Lab Muffin Beauty Science


Lab Muffin Beauty Science

In-depth reviews of broad spectrum SPF 50+ facial sunscreens available in Australian stores, from brands Cetaphil, Elucent, Alpha-H and Sunsense.

UK STOCK Biore UV Aqua Rich Watery Essence Water Base SunScreen SPF50+/PA++++  | eBay

UK STOCK Biore UV Aqua Rich Watery Essence Water Base SunScreen SPF50+/PA++++ | eBay


eBay

Contains unique Aqua Micro Capsules with UV block ingredient to provide superior SPF 50 /PA protection while keeping skin cool and refreshed. It is enriched with Hyaluronic Acid amp; Citrus essence to hydrate and soften skin. | eBay!

Going sulphate free

by noreply@blogger.com (Kim O) @ And now for something similar...

It seems like the beauty world is getting more clued up on sulphates recently. There are many more options in the shops for sulphate free shampoos now, such as the L'oreal Eversomething range and many others. I have mentioned the advantages to using sulphate free shampoos in my "Keeping unnatural hair happy" post but I have never really though about cutting sulphates out from the rest of my life. Until now.

For the last week I have been using a pretty strong retinoid. If you want to know more about retinoids then Skinacea is a great website to swot up, but in general terms, it is a prescription gel or cream (you can get weaker versions over the counter) that does wonders for acne and anti-aging. But it does come with some side effects. At first your skin can peel very badly, and you go through a stage of purging, where any spots or clogged pores that you have beneath the surface of the skin come to a head. That's what I've been going through the last few days, and I realised something whilst looking in the mirror. Pretty much all my spots are around my chin area. I knew I had clogged pores there, but I had no idea how many I had until I went through my purging stage. And how come there are so many in that particular place? And then it hit me, my toothpaste! One of the top ingredients in my (and many other toothpastes) is Sodium Lauryl Sulphate. It can cause ulcers, sore skin and irritation and clogged pores. Now don't get me wrong, it's not dangerous, and I have been using regular toothpaste with sulphates for all of my life, but I've alwyas wondered why occasionally my mouth gets sore in the corners of my lips, and now I think I've hit the nail on the head. I headed out to Superdrug and purchased some Sensodyne, which is sulphate free. I'll keep you updated on the progress!

Another thing which I wouldn't have even thought about was how I clean my make up brushes. I saw a post on the internet by someone who was having terrible trouble with her skin. She kept it clean and moisturised, she used gentle products, slept on clean pillows and washed her make up brushes regularly, but she said everytime she used her make up brushes they broke her out. Now that shouldn't happen. If you are using dirty make up brushes then yes, but clean ones? Then someone asked what she was using to wash her make up brushes and she replied that it was a regular shampoo. With sulphates! Now your skin may not be that sensitive to sulphate that you break out simply by using a brush that has been cleansed with a product that contains them, but it is worth thinking about. I think I'm going to switch from using cheap shampoo, to a mixture of washing up liquid and almond oil in the future.

Sodium Lauryl Sulphate is a foaming agent that is found in so many products, from hair care, to facial cleansers and toothpaste. While it's not bad for you (like I say, for many many years pretty much all of my products contained Sodium Lauryl Sulphate) it is kind of a unnecessary additive that can cause more negative side effects than positive. Do I really want clogged pores on my chin just so my toothpaste is more frothy? Do I really want my hair colour to fade quicker just because I can get more of a lather when washing my hair? With more people thinking more carefully about the ingredients in the products they buy, a lot more sulphate free products are available, and not really any more expensive, so why not try giving up sulphates for a while? See if you can see any difference.

Why You Shouldn't Be Buying Your Sunscreen in America

Why You Shouldn't Be Buying Your Sunscreen in America


Racked

When Kristin Francis, a consultant living in Jersey City, visits Europe, she comes home with bottles of foreign sunscreen. Francis considers sunscreen from Europe the perfect souvenir, seeing as...

Why do some turtles outlive humans?

by @ Articles - Articles

(⇒ write for LongeCity )


The oldest human recorded in modernity was Jeanne Louise Calment, she died in the age of 122 years and 164 days [1] .

There are rumors that the oldest tortoise called Adwaita (Aldabra giant tortoise) died in the age of about 250 years [2] or that it was 188-year-old radiated tortoise named Tui Malila [3] , or that the highest verified age of 177 years had Galapagos giant tortoise Harriet [4] . The oldest currently living turtle is considered to be Jonathan (Seychelles giant tortoise), estimated to be over 180 years old these days [5] . Although all aforementioned numbers are estimations, it seems these turtles were older than human supercentenarians.

All previously mentioned species are terrestrial tortoises, a group with longest lifespans among turtles. The most famous of them, well-researched Galapagos giant tortoise, was observed by Charles Darwin when he was forming his well-known theory of evolution by natural selection [6] . There is only one freshwater turtle known to be able to outlive human, it is the common snapping turtle estimated to live up to more than hundred years [7] . While being considerably less researched, recorded maximal lifespan of sea turtles is usually shorter, not exceeding 80 years, however, it is believed that the green sea turtle can live up to 100 years. [8]

It is a difficult question to answer why these reptiles can outlive us because even to determine the actual age of animals with a long lifespan is complicated – partially due to the fact that it takes such a long time to study. Furthermore, many turtles are endangered species [9] so there may not be as many organisms to hand as needed for proper statistics. Nonetheless, we can still claim that turtles are among the most long-living vertebrates on earth [10] . Why?

Firstly, turtles, like all reptiles, benefit from being ectothermic organisms. They do not maintain body temperature and thus save a lot of energy. But that also means they are less flexible: it is crucial for their lifespan to be in natural temperature environment of daily cycles with night-time temperature drop [11] . If they do not live under these conditions in captivity, metabolic pathways change and turtles die much sooner. [12]

Turtles are well-adapted in other ways: their famous shell – the carapace –is good protection against natural predators. Most of hatchling turtles with a soft shell do not survive the first year [13] . A research of natural populations of freshwater turtles showed that only one per cent of them can celebrate the twentieth birthdays, but once the adulthood is reached, mortality rate drops and remains constant throughout the rest of life [14] .

Some turtles can survive under extreme environmental conditions, such as freezing [15] or lack of oxygen for months [16] . They can even undergo hibernation and anaerobic metabolism and therefore deal with hypoxia and anoxia, it was also proposed that the same genes can play a role in longevity itself [17] and also in oxidative stress resistance [18] that further promotes longer life [19] .

Turtle’s bones and shell are used as lactate buffer lowering metabolic acidosis caused by anaerobic glycolysis during the period of lack of oxygen [20] ; [21] Their organism is protected by strong innate immunity compensating slow acquired immune reactions [22] .

Because turtles have very slow metabolism as well as growth, their bodies do not need to deal with excessive metabolic heat and byproducts as mammals [23] . Their natural diet is very simple but also necessary for their longevity. [24]

According to the evolutionary theories, staying alive is less important after menopause. Galapagos giant tortoises achieve sexual maturity late (around the age of up to forty years in the wild, and between twenty and twenty-five years of life in captivity [25] ), then staying fertile until death [26] .

The Hayflick limit is said to determine how many times a cell can divide [27] . The Hayflick limit of Galapagos giant tortoise was said to be about 110 divisions [28] , approximately twice as many as 50 of human cells [29] . Studies in this context have highlighted the importance of telomeres, the protective end sequences of chromosomes, that get shorter with each cell division [30] , can play at least a partially role in life expectancy. It was observed that telomeres in European freshwater turtle’s cells are of the same length in both embryo and adult organism [31] .

Thus, it was believed that turtles are negligibly senescent organisms [32] . In other words, the cells do not age and no age-related diseases appear, which is very different cell behavior than in human bodies [33] and probably the key to any natural longevity. However, evidence now suggests that turtles may not be really negligibly senescent because of observations of survival and reproductive senescence in late age in the painted turtle population [34]

As we can see, turtles have some advantages in the lifespan field. Some of these might inspire researchers to increase lifespans in humans.



References

[1] Oldest person ever. Retrieved January 31, 2017, from http://www.guinnessworldrecords.com/world-records/oldest-person
[2] BBC (2006, March 23). “Clive of India’s” tortoise dies. BBC South Asia. Retrieved from http://news.bbc.co.uk/2/hi/south_asia/4837988.stm
[3] Associated Press (2006, June 26). Tortoise believed to have been owned by Darwin Dies at 176. Fox News. Retrieved from http://www.foxnews.com/story/2006/06/26/tortoise-believed-to-have-been-owned-by-darwin-dies-at-176.html
[4] Galapagos tortoise (Geochelone nigra) longevity, ageing, and life history. Retrieved January 31, 2017, from http://genomics.senescence.info/species/entry.php?species=Geochelone_nigra
[5] Hollins, J. (2012). The world’s most isolated vet? Veterinary Record, 171(2), i–i. doi:10.1136/vr.g7292
[6] Powell, J., & Caccone, A. (2006). Giant tortoises. Current Biology, 16(5), R144–R145. doi:10.1016/j.cub.2006.02.050
[7] Cameron, M. (2008). COSEWIC Assessment and Status Report on the Snapping Turtle Chelydra serpentina in Canada . Retrieved from http://publications.gc.ca/collections/collection_2009/ec/CW69-14-565-2009E.pdf
[8] Green sea turtle (Chelonia mydas) longevity, ageing, and life history. Retrieved January 31, 2017, from http://genomics.senescence.info/species/entry.php?species=Chelonia_mydas
[9] Jacobson, E. R. (1994). Causes of Mortality and Diseases in Tortoises: A Review. Journal of Zoo and Wildlife Medicine, 25(1), 2–17.
[10] Gibbons, J. W. (1987). Why do turtles live so long? BioScience, 37(4), 262–269. doi:10.2307/1310589
[11] Flouris, A. D., & Piantoni, C. (2014). Links between thermoregulation and aging in endotherms and ectotherms. Temperature, 2(1), 73–85. doi:10.4161/23328940.2014.989793
[12] Vadala, N. How Long Do Turtles Live? Retrieved January 31, 2017, from http://www.petmd.com/reptile/care/how-long-do-turtles-live
[13] Stewart, K. R., & Wyneken, J. (2004). Predation risk to loggerhead hatchlings at a high-density nesting beach in Southeast Florida. Bulletin of Marine Science, 74(2), 325–335.
[14] Gibbons, J. W., & Semlitsch, R. D. (1982). Survivorship and longevity of a long-lived vertebrate species: How long do turtles live? The Journal of Animal Ecology, 51(2), 523. doi:10.2307/3981
[15] Packard, G. C., & Packard, M. J. (2003). Natural freeze-tolerance in hatchling painted turtles? Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 134(2), 233–246. doi:10.1016/s1095-6433(02)00264-7
[16] Milton, S. L., & Prentice, H. M. (2007). Beyond anoxia: The physiology of metabolic downregulation and recovery in the anoxia-tolerant turtle. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 147(2), 277–290. doi:10.1016/j.cbpa.2006.08.041
[17] Shaffer, H. B., Minx, P., Warren, D. E., Shedlock, A. M., Thomson, R. C., Valenzuela, N., … Wilson, R. K. (2013). The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage. Genome Biology, 14(3), R28.doi:10.1186/gb-2013-14-3-r28
[18] Garbarino, V. R., Orr, M. E., Rodriguez, K. A., & Buffenstein, R. (2015). Mechanisms of oxidative stress resistance in the brain: Lessons learned from hypoxia tolerant extremophilic vertebrates. Archives of Biochemistry and Biophysics, 576, 8–16. doi:10.1016/j.abb.2015.01.029
[19] von Zglinicki, T. (2002). Oxidative stress shortens telomeres. Trends in Biochemical Sciences, 27(7), 339–344. doi:10.1016/s0968-0004(02)02110-2
[20] Jackson, D. C. (2000). Living without oxygen: Lessons from the freshwater turtle. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 125(3), 299–315. doi:10.1016/s1095-6433(00)00160-4
[21] Krivoruchko & Storey, 2010).
[22] Sandmeier, F. C., Tracy, C. R., Dupre, S., & Hunter, K. (2012). A trade-off between natural and acquired antibody production in a reptile: Implications for long-term resistance to disease. Biology Open, 1(11), 1078–1082. doi:10.1242/bio.20122527
[23] Bilinski, T., Paszkiewicz, T., & Zadrag-Tecza, R. (2015). Energy excess is the main cause of accelerated aging of mammals. Oncotarget, 6(15), 12909–12919. doi:10.18632/oncotarget.4271
[24] Casares, M., Honegger, R. E., & Rubel, A. (1995). Management of giant tortoises Geochelone elephantopus and Geochelone gigantean at Zurich Zoological gardens. International Zoo Yearbook, 34(1), 135–143. doi:10.1111/j.1748-1090.1995.tb00671.x
[25] Global, S. D. Z. (2010). Galapagos tortoise fact sheet. Retrieved January 31, 2017, from http://library.sandiegozoo.org/factsheets/galapagos_tortoise/tortoise.htm
[26] Curtin, A. J., Zug, G. R., & Spotila, J. R. (2009). Longevity and growth strategies of the desert tortoise (Gopherus agassizii) in two American deserts. Journal of Arid Environments, 73(4-5), 463–471. doi:10.1016/j.jaridenv.2008.11.011
[27] Hayflick, L. (1965). The limited in vitro lifetime of human diploid cell strains. Experimental Cell Research, 37(3), 614–636. doi:10.1016/0014-4827(65)90211-9
[28] Goldstein, S. (1974). Aging in vitro. Experimental Cell Research, 83(2), 297–302. doi:10.1016/0014-4827(74)90342-5
[29] Hayflick, L., & Moorhead, P. S. (1961). The serial cultivation of human diploid cell strains. Experimental Cell Research, 25(3), 585–621. doi:10.1016/0014-4827(61)90192-6
[30] Harley, C. B., Futcher, A. B., & Greider, C. W. (1990). Telomeres shorten during ageing of human fibroblasts. Nature, 345(6274), 458–460. doi:10.1038/345458a0
[31] Girondot, M., & Garcia, J. (1999). Senescence and longevity in turtles: What telomeres tell us. 9th extraordinary meeting of the societas Europaea Herpetologica, 1, 25–29. Retrieved from //www.researchgate.net/publication/252290006_Senescence_and_longevity_in_turtles_What_telomeres_tell_us
[32] Miller, J. K. (2001). Escaping senescence: Demographic data from the three-toed box turtle (Terrapene carolina triunguis). Experimental Gerontology, 36(4-6), 829–832. doi:10.1016/s0531-5565(00)00243-6
[33] Schächter, F., Cohen, D., & Kirkwood, T. (1993). Prospects for the genetics of human longevity. Human Genetics, 91(6), . doi:10.1007/bf00205074
[34] Warner, D. A., Miller, D. A. W., Bronikowski, A. M., & Janzen, F. J. (2016). Decades of field data reveal that turtles senesce in the wild. Proceedings of the National Academy of Sciences, 113(23), 6502–6507. doi:10.1073/pnas.1600035113

LongeCity Affiliate Labs

by @ LongeCity - Articles

The Longecity “Affiliate Labs” are small, research-focused enterprises or independent academic research groups led by a scientists with strong ties to the Longecity community and a proven track record of commitment to scientific inquiry directly relevant to the Longecity mission.
These leaders and their colleagues are not just trailblazers in advancing important areas of regenerative and rejuvenation research, but also incredibly helpful when there is a community need for peer review, when providing advice and training to a young scientist, and in providing the expertise and tools to test the novel, controversial, or promising scientific leads sourced from the Longecity community and beyond.

Community Funding
There is a small support fund that the labs can draw on to flexibly support their research activities. While not a substitute for private investment and public sector grants, the ability to flexibly ‘just try’ out a new idea without needing to ‘pitch’ in lengthy proposals can be an invaluable accelerator to research progress. All Affiliates have an active link to the Longecity community, so there is a level of accountability and responsiveness beyond anything encountered in ‘traditional’ research donations.
By donating to the Affiliate Labs fund, Members can be assured that every penny goes directly to an expert personally and professionally committed to making a difference in the scientific conquest of death.
Donate HERE

Current Affiliate Labs
- Alexandra Stolzing, Loughborough University, UK & Leipzig University, Germany.
- João Pedro de Magalhães, University of Liverpool, UK
- Kelsey Moody, Ichor Therapeutics, USA.
- Kevin Perrott – Buck Institute, USA
- Matthew O’Connor – SENS Foundation, USA

Anessa Sunscreen Gold vs Silver! 2017 version - Wonect.Life

Anessa Sunscreen Gold vs Silver! 2017 version - Wonect.Life


Wonect.Life

Anessa sunscreen 2017. Reformulated, new products, all powerful! Find out how to choose among the most popular Japanese sunscreens!

8 best micellar cleansing waters

8 best micellar cleansing waters


The Independent

Sometimes keeping up with a complex skincare routine can be too much. From exfoliating to cleansing to toning to moisturising, it’s hard to keep up with what you’re supposed to be doing when. A micellar cleanser cuts out some of those steps, acting as a make-up remover, cleanser and toner in one swipe. Micellar waters are a non-rinsing formula, so you just need to apply to the face with a cotton pad, as you would a toner, making them perfect for those days when you don’t have time for a hot cloth cleanse.

LongeCity and others

by @ LongeCity - Articles

A) Background


LongeCity's origins lie with a personal website: On his private page where he chronicled his engagement with life extension, Bruce Klein also maintained a private bulleting board 'home for immortals'. Soon, visitors reached a critical mass.

And then it happened: Rather than staying at that level, we transcended it together. Bruce agreed to give up his control for something greater: the 'Immortality Institute' was founded as a members-based organisation.

 

This 'big tent' approach stood the test of time: Protagonists came and went, the original founders passed on the torch. The organisation endured, because it was no longer any individuals private agenda, it became an idea, a mission, and a community. We have left the days of the founding behind. We even changed our name, but, as an acknowledgement to this first, bold step into a unique community, LongeCity still refers to its internal Members section as the 'Immortality Institute' and remains open to Members from across the globe.


Also, until this day, our history shapes how we look at working with others: we celebrate the fantastic potential that lies in each person's own initiative and seek to empower individuals to pursue exactly those projects they feel passionate about, but we also try to link, to integrate, to join together and to collaborate in a broader context for maximum effect.

 


B) Private Individuals and their efforts/websites


There are many of personal websites around of the type Bruce started with. Some are just one person's way of discovering a new field, others grow into great resources or global benefit.
The great thing about them is the freedom they give you as the author to manage them largely as you please. Downsides exist: personal websites often have limited circulation beyond a particular social sphere or topic, missing chances for cross-pollination. A lot of energy is spent on re-inventing the wheel many times over, while it could be more productively channelled into improving what is already there. Mainly, they are fickle things, and anyone with internet experience learns not to trust them remaining as they often grind to a halt or disappear as the sole author/owner gets engaged in other priorities.

 

So on balance, LongeCity aims to make it easy for people to contribute directly to a larger pool. Members can have their own webspace or blogs or fora or linklists etc. without needing to home brew. If they want control, they can have as much as possible as long as it doesn't clash with others. (1)

On the other hand, some people only tap their full potential if they feel a project is fully and entirely their own.
IF that aspect is important to you, then please, by all means, do your own thing! We would much rather let a thousand flowers bloom than no growth at all. For maximum benefit, maybe you could still cross-reference to LongeCity?  (2)


C) Other initiatives and Organisations  


Now, this is a slightly more complicated topic.(3)

LongeCity understands itself as part of a movement. As usual in any movement, there are different preferences, protagonists, perspectives, powers and priorities. On the one hand, there is a real opportunity cost associated with not combining forces. It is sometimes very difficult to wish people good luck in setting up their own initiatives when, very clearly, their creative and financial resources could be much more effectively leveraged by using existing links and mechanisms.


On the other hand, different approaches and competition are absolutely essential to ensure that as many paths for success as possible are being pursued. LongeCity does not exist for its own sake. If it was not clear that we can make a unique contribution to the greater cause, we would close down and direct everyone to other initiatives. We need to be clear about what contribution we are making, when others are doing a better job and also when we are duplicating or being duplicated and why.

 

To all similar initiatives out there: If it looks like we are doing something very similar, please lets discuss if there are ways to generate greater synergies. This may simply mean that we stay in touch, it could mean collaboration on specific projects or it might go as far that LongeCity stops doing something and leaves it to you. OR you might decide to do what you are doing as part of LongeCity.

Two things in particular, we would much prefer to collaborate on:
1) if you are doing anything that involves a forum, we would be thrilled if you could do that at LongeCity. Over the years we have seen so many forums come and go, that we really think it a great shame to reinvent the wheel time and again. We'd gladly give you all the support and 'moderation' powers to run your own forum section at LongeCity, and a suite of powerful IT tools together with a great deal of experience as well.

2) if you are blogging or writing regular articles on life extension. Again, it is a great shame to see so many fantastic contributions swept away in the winds of time, whereas they could have been archived at LongeCity. We can easily supply you with all the tools and support, in fact we might even be able to pay you a little bit of money for your efforts - and the copyright still stays with you!

In summary, we have a mission, but not a specific 'line'. Instead we want to be a 'city'- a place where people come together. A place where different 'homes' exist fruitfully together, an umbrella group and a forum for exchange.
We would like to be a 'one-stop' info point for life extension on the web, from which people can move on to pick exactly those aspects or initiatives -at LongeCity or elsewhere- that they like. Any fellow initiatives out there, please get in touch to help make that vision a reality from which everyone benefits.

 


D) Advertisers at LongeCity 


This is a slightly different topic. Anyone who visits LongeCity will not fail to notice that it attracts the attention of people who do not care much about our mission. Some come to debate, many to learn about nutrition (but not with an ultimate interest in life extension), some try to make money. To be quite frank, part of LongeCity's particular approach is to try to extract funds from these dynamics in order to re-allocate them towards the common mission. In this context, we sometimes partner with advertisers. Now, we do in fact discuss each advertiser internally and have rejected quite a few as not something we would affiliate with. However, at the end of the day the imperative is to raise money for a cause that we consider of life-saving importance. In that context we do not necessarily choose advertisers based on their own, (or their products) life-extension credentials. LongeCity does not endorse any advertisers beyond the fact that they have made a donation to the community in exchange for exposure. Advertisers never influence our policy, ever. Advertisers get banners (please click on them) -- thats it.
Having said that, advertisers featured at LongeCity very often have a real commitment to the cause- they would not have found us otherwise. When we say something nice about an advertiser, then that is NOT something they paid for but a genuine observation regarding their conduct and contribution to the cause.

 


E) Members representing LongeCity?

 

Membership of LongeCity is a strange thing: On the one hand, its a strictly in-or-out affair. On the other, Membership is just one way (and perhaps not a good one) to differentiate the 'talkers' from the 'doers'. If you are clearly a 'doer' we would probably consider you a Member of the life extension community whether you have joined the Immortality Institute or not. One way of simulating that is to give people 'points' for activities in connection with LongeCity. If you get enough points, Membership is free. Anyone who wants to join LongeCity but can't afford the (very modest) Membership donation, please get in touch, we have never denied membership to a committed peer based on inability to pay.
LongeCity is an open place. Membership as such does not entail 'vetting'.(4)

We hope that our Members conduct themselves in an exemplary manner that reflects well on the broader community at all times. But clearly, this is not always on the cards, not least because we are deliberately opening our doors to a diverse range of backgrounds and perspectives. Thus, whether someone is a Member does not mean that this person is in any way representative of our Membership or can speak on behalf of the organisation.

What about leadership? The case is not too different. Really, the only requirement to move into a leadership position at LongeCity is some tangible commitment. We don't vet people apart from a very basic appointment review and a requirement to sign the leadership agreement. Directors and certain key officers are asked for ID, but that's about it. Now, leaders *are* expected to behave in certain ways when representing LongeCity. Clearly, they owe as much to the Membership and community. But when not wearing the LongeCity hat, leaders are free to express their views and pursue their activities as they please and without any review by LongeCity. Some leaders may have gone on to do some strange things in their lives – LongeCity does not pry into a persons private affairs, successes or failures, ventures or missteps as long as it does not affect or organisation, community and mission.
If there is uncertainty whether a LongeCity leader is doing something in an official capacity, the fault is with us for allowing this ambiguity to prevail- please let us know and we'll make sure to clarify the situation.

 


F) CONCLUSION

 

The above are observations that I make from the Chair... but with the proviso that this perspective and policy might well change as time moves on – as you have seen from our history LongeCity is certainly able to evolve!
I hope the above is useful as a reference point regarding how LongeCity relates to 'others'. I also hope it has become clear that we really don't see a lot of 'others'. Anyone who shares our mission is 'one of us'. People interested in life extension are often individualists -- and any talk of a 'community' will need to take this into account. But mindful of this fact, as gently and effectively as possible, LongeCity aspires to provide a hospitable 'home' for a community, for diverse communitIES and lone travellers alike.  

 

 

 

Footnotes:

 

(1) A good example of such a compromise are forum threads: A new discussion is initiated by a 'threadstarter'. A certain amount of responsibility comes with selecting a good topic, framing it well, giving it a good exposition. It can be frustrating if people spoil 'your' thread with inappropriate remarks. On your own website, you could just remove comments at will. On LongeCity, Members can ask to become Moderators of their own threads. It should be made clear in the first post if that option is used, so that other contributors are aware of this.

 

(2) For example, did you know that you can maintain a blog externally, AND a 'mirror' blog at LongeCity? Every post you make in your own blog can be automatically imported into your LongeCity blog. Ask if you need help setting this up.

 

(3) A reference to the 'Life of Brian' may help to set the scheme in a humorous way:

 

(4) There are some conditions of membership --they are listed in our bylaws, and I shan't go into them here, but suffice it to say that it is not very difficult to join. Very few Members have ever been expelled and where that happened it was based on activities that were directly in connection with activities on the site. While Members might sometimes be rebuked or even banned from posting on our public forums, even that does not entail automatic removal of Membership.    

 

 

Sunscreen Round Up and Comparison! (Biore, Missha, Vichy)

Sunscreen Round Up and Comparison! (Biore, Missha, Vichy)


Twenty Swans

You know what? I recently did a review and mentioned how I was not into skincare as much as I usually am, and now I am on it again, scouring skincare instead of makeup online. This was unexpected. …

Zinc Oxide Sunscreens - Ageless Looks

Zinc Oxide Sunscreens - Ageless Looks


LONGECITY

Page 1 of 2 - Zinc Oxide Sunscreens - posted in Ageless Looks: I prefer to use a zinc oxide based sunscreen, and have tried several (often imported from the USA as there arent as many available in the UK). The best ones Ive found seem to include a low percentage (around 7% or so) of non-nano zinc oxide, or a higher percentage (17% or more) of nano zinc oxide. It seems that UVA1 protection is not as good with nano particles, but would that be balanced out by the higher percentage?...

Video: All Your Sunscreen and Make-up Questions Answered

by Michelle @ Lab Muffin Beauty Science

Or at least I hope all your sunscreen and make-up questions are answered! This video took me a bloody long time to research and put together, so I’m hoping I won’t have to revisit this topic again anytime soon. The questions I talk about: Do I need to wear sunscreen every day, even though I’ll...

Read More »

The post Video: All Your Sunscreen and Make-up Questions Answered appeared first on Lab Muffin Beauty Science.

Is glycation from exogenous ribose supplementation an issue?

by @ ImmInst Active Topics

Life extension published this article on ribose, which seems to refute the concern about glycation (over and above other carbs) please debate.

From : http://www.lifeextension.com/Magazine/2012/10/Restoring-Cellular-Energy-Metabolism/Page-02

"Fibromyalgia
Fibromyalgia (FM) and chronic fatigue syndrome are conditions that often occur together and are believed to have a similar underlying cause.28

There's accumulating evidence that defective production of ATP is the culprit.28-30 These findings make d-ribose a natural candidate as a therapy for those suffering from fibromyalgia and chronic fatigue syndrome. A published case study showed that a woman with fibromyalgia experienced a decrease in symptoms following supplementation with d-ribose.31 The patient had been unresponsive to prior medications, and her physicians based their decision on the known energy-enhancing capabilities of d-ribose.

A larger study soon followed enlisting 41 patients with fibromyalgia or chronic fatigue syndrome.28 Subjects took 5 grams of d-ribose three times daily until they reached a total of 280 grams.

There was significant improvement in all five categories on a standard score: energy, sleep, mental clarity, pain intensity, and well-being.28 On average, patients reported a 45% increase in energy levels.

While fibromyalgia and chronic fatigue syndrome remain complicated and perplexing to scientists, these findings offer real hope for a solution.

Restless Leg Syndrome
Restless Leg Syndrome
Restless leg syndrome (RLS) is a common disorder that affects as many as 15% of the US population, and it is severe enough to warrant medical treatment in more than a third of those people.32,33

The condition involves an uncontrollable urge to move the legs, accompanied by uncomfortable sensations, and it is usually worse at night.33 Only a few medications offer even partial relief of restless leg syndrome, and many make the condition worse—leaving sufferers without much recourse.32,33

Disordered energy metabolism has been suggested as one possible cause of restless leg syndrome. Low levels of adenosine, the d-ribose-containing central molecule in ATP, have been reported in those suffering from restless leg syndrome.34

Based on that observation, one study has been carried out in which daytime symptoms were eliminated, and nighttime symptoms significantly reduced, on daily doses of 15 grams of d-ribose, taken as one 5-gram dose with breakfast, lunch, and dinner.26

It's clearly too early to claim that d-ribose cures the condition, but these encouraging findings—coupled with complete absence of side effects—warrant further investigation.

UNGROUNDED FEAR: CAN D-RIBOSE CAUSE GLYCATION REACTIONS?
It is now generally accepted that d-ribose supplementation provides many health benefits, particularly in the area of cellular energy management.

Several recent publications, however, have raised the question of whether d-ribose—because it is a sugar—could possibly contribute to development of harmful advanced glycation endproducts.40-43

The truth seems to be straightforward: Like any sugar, ribose can indeed cause protein glycation, with resulting damage to tissues.42 And when ribose is administered experimentally at the same high dose as glucose, ribose quickly causes the protein cross-linking that is the outcome of glycation.40

But those studies used artificially high doses and concentrations of ribose, levels never found in humans—even after high-dose supplementation.

For example, in a human study of d-ribose supplementation at doses of 20 and 53 grams over a 4-hour period, peak serum ribose levels rose to only 4.8 mg/dL and 81.7 mg/dL, respectively.44

But doses used in the glycation experiments were significantly higher, up to 30 times higher than achievable in human blood!42,43

And in an experiment showing that d-ribose induced glycation and impaired spatial cognition in mice, the ribose concentrations used were equivalent to blood levels of 150 to 750 mg/dL, clearly vastly higher than have been used in human studies.43,44

Researchers seeking to show that ribose-induced glycation could enhance cartilage damage in an animal model of osteoarthritis showed conclusively that even direct injection of ribose into the joint was incapable of triggering sufficient glycation to cause injury!45,46

The doses for d-ribose studies reported in this article—15 to 60 grams per day in divided doses—are incapable of causing serum ribose concentrations high enough to get anywhere near the risk of excessive glycation reported in the lab studies.44

Also, most human studies recommended splitting the total amount into three daily doses; this approach provides even greater assurance that serum d-ribose remains well within safe levels.

Kidney Protection
Like the brain and heart, the human kidney receives a a high proportion of the body's total blood flow—which makes it equally vulnerable to damage by ischemia-reperfusion mechanisms, the loss and restoration of blood flow.

These kidney injuries can occur as the result of trauma or during any major surgery, sometimes worsened by chronic conditions such as cardiovascular disease and diabetes.35-37

Growing evidence suggests that an immune activation and inflammatory response following this kind of kidney injury creates the bulk of the damage, especially in those with diabetes.12,38 Adenosine, which is partly made from d-ribose, is an important regulator of kidney function, and is especially vital during times of injury.39 These observations—coupled with what we know about d-ribose as antioxidant and anti-inflammatory—have aroused considerable interest among kidney researchers.

Japanese scientists have led the way in investigating d-ribose as a kidney protector. They have found that in rats subjected to renal ischemia-reperfusion—similar to what can occur during major surgery—d-ribose significantly reduced the release of inflammatory cytokines.12 Kidney function and appearance following the injury was improved substantially.

They also showed that d-ribose reduces activation of neutrophils, the ubiquitous white blood cells that are the first to arrive at the scene of an injury but that also release toxic chemicals and oxygen radicals that can cause additional harm.11

Clearly researchers are only beginning to realize the substantial potential of d-ribose for kidney health.

Summary
D-ribose is an essential component in our bodies' cellular energy management systems. Additionally, it provides antioxidant, anti-inflammatory, and gene regulatory capabilities. Together these characteristics make it of compelling interest to forward-thinking clinicians and patients.

Supplemental d-ribose demonstrates cardioprotection—even late in the disease process when heart attacks have already occurred, and when heart failure is developing. D-ribose helps ailing heart muscle maximize its effort, and improves blood flow to oxygen-starved cardiac tissue.

D-ribose supplements are only just being explored for similar benefits in brain and kidney tissues, but recent studies offer great hope in those areas. Even perplexing conditions such as fibromyalgia and restless leg syndrome seem to be yielding to the energy-related benefits of d-ribose. •


References
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15. Kendler BS. Supplemental conditionally essential nutrients in cardiovascular disease therapy. J Cardiovasc Nurs. 2006 Jan-Feb;21(1):9-16.

16. Sinatra ST. Metabolic cardiology: an integrative strategy in the treatment of congestive heart failure. Altern Ther Health Med. 2009 May-Jun;15(3):44-52.

17. Lopaschuk GD. Treating ischemic heart disease by pharmacologically improving cardiac energy metabolism. Presse Med. 1998 Dec 12;27(39):2100-4.

18. Pauly DF, Johnson C, St Cyr JA. The benefits of ribose in cardiovascular disease. Med Hypotheses. 2003 Feb;60(2):149-51.

19. Sinatra ST. Metabolic cardiology: the missing link in cardiovascular disease. Altern Ther Health Med. 2009 Mar-Apr;15(2):48-50.

20. Hegewald MG, Palac RT, Angello DA, Perlmutter NS, Wilson RA. Ribose infusion accelerates thallium redistribution with early imaging compared with late 24-hour imaging without ribose. J Am Coll Cardiol. 1991 Dec;18(7):1671-81.

21. Omran H, Illien S, MacCarter D, St Cyr J, Luderitz B. D-Ribose improves diastolic function and quality of life in congestive heart failure patients: a prospective feasibility study. Eur J Heart Fail. 2003 Oct;5(5):615-9.

22. Omran H, McCarter D, St Cyr J, Luderitz B. D-ribose aids congestive heart failure patients. Exp Clin Cardiol. 2004 Summer;9(2):117-8.

23. Schneider HJ, Rossner S, Pfeiffer D, Hagendorff A. D-ribose improves cardiac contractility and hemodynamics, and reduces expression of c-fos in the hippocampus during sustained slow ventricular tachycardia in rats. Int J Cardiol. 2008 Mar 28;125(1):49-56.

24. Sawada SG, Lewis S, Kovacs R, et al. Evaluation of the anti-ischemic effects of D-ribose during dobutamine stress echocardiography: a pilot study. Cardiovasc Ultrasound. 2009;7:5.

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36. Siems W, Quast S, Carluccio F, et al. Oxidative stress in chronic renal failure as a cardiovascular risk factor. Clin Nephrol. 2002 Jul;58 Suppl 1:S12-9.

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38. Jang HR, Ko GJ, Wasowska BA, Rabb H. The interaction between ischemia-reperfusion and immune responses in the kidney. J Mol Med. 2009 Sep;87(9):859-64.

39. Vallon V, Osswald H. Adenosine receptors and the kidney. Handb Exp Pharmacol. 2009 (193):443-70.

40. Mentink CJ, Hendriks M, Levels AA, Wolffenbuttel BH. Glucose-mediated cross-linking of collagen in rat tendon and skin. Clin Chim Acta. 2002 Jul;321(1-2):69-76.

41. Kuo TY, Huang CL, Yang JM, et al. The role of ribosylated-BSA in regulating PC12 cell viability. Cell Biol Toxicol. 2012 Aug;28(4): 255-67.

42. Wei Y, Han CS, Zhou J, Liu Y, Chen L, He RQ. d-ribose in glycation and protein aggregation. Biochim Biophys Acta. 2012 Apr;1820(4):488-94.

43. Han C, Lu Y, Wei Y, Liu Y, He R. D-ribose induces cellular protein glycation and impairs mouse spatial cognition. PLoS One. 2011;6(9):e24623.

44. Gross M, Zollner N. Serum levels of glucose, insulin, and C-peptide during long-term D-ribose administration in man. Klin Wochenschr. 1991 Jan 4;69(1):31-6.

45. Vos PA, Degroot J, Barten-van Rijbroek AD, et al. Elevation of cartilage AGEs does not accelerate initiation of canine experimental osteoarthritis upon mild surgical damage. J Orthop Res. 2012 Mar 2.

46. Willett TL, Kandel R, De Croos JN, Avery NC, Grynpas MD. Enhanced levels of non-enzymatic glycation and pentosidine crosslinking in spontaneous osteoarthritis progression. Osteoarthritis Cartilage. 2012 Jul;20(7):736-44."

8 EWG Sunscreen Picks When You’re in a Pinch

by Leah Zerbe @ Dr. Axe

EWG sunscreen ratings serve as a lifeline for people who want to use sunscreen without all of the toxic ingredients. For more than a decade, EWG (the non-profit Environmental Working Group) takes on the annual task of sifting through sunscreen label claims, ingredient lists and scientific studies analyzing what’s really in those sunblock bottles. I know I’m... Read more »

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