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Biore Watery Essence Uk

ChitChat Korea & Thailand Plastic Surgery

by Thiwie @ Female Daily Forum

Mohon izin buat thread ini untuk sharing informasi tentang Operasi plastik khusus di Korea dan Thailand ya ladiesss :welcome: sedikit informasi...

MishiBox Reveal & Review July 2016 - Boxnip

MishiBox Reveal & Review July 2016 - Boxnip


Boxnip

New box time! YAY!! I decided to try MISHIBOX back in July and of course because it has to come from the US I get it considerably later BUT I honestly don’t mind. So, what exactly is MISHIBOX? I’ll quote what it says on their website:- Our mission at MISHIBOX(pronounced “me-she”) is to help you explore the exciting (and sometimes very cute) world of Korean beauty. We want to help you discover your favorite products in a convenient, effortless, and affordable way. We will send you a curated box with a combination of 5 – 6 deluxe-sized samples and full-sized Korean…

UPDATE: Skinlycious, Aztec Indian Healing Clay, Kinohimitsu BB Drink

by noreply@blogger.com (Wenxuan) @ Wild Flower

Hi guys,

I'm glad to check back and say that I am really satisfied with Skinlycious' products, they have helped me tremendously. I've even repurchased the Anti-Acne bundle for the second time. The products last me about a month plus to 2 months! It may last longer for some of you, but I'm quite kiasu so the first month I didn't know how to control my usage. Lol. Anyway, my skin is less oily now, and I haven't even used up the 7-in-1 Pore Refining Serum.

Current skincare routine

AM:
Skinlycious Anti-Acne Wash
Skinlycious Anti-Acne Solution (Dab on spots and hyperpigmentation)
Hiruscar Post-Acne Gel (On hyperpigmentation as well)
Skinlycious 7-in-1 Pore Refining Serum (if I'm heading out) or Skinlycious Hydrator Serum (if my skin is feeling slightly drier) or The Skin Pharmacy's Oil-free moisturiser (if I'm staying at home because this moisturise doesn't mix well with my make up! It makes my foundation roll up into tiny balls)
Atomy Sunscreen
Urban Decay Naked Weightless Liquid Foundation (2 small drops are enough)
Maybelline Mineral Concealer (I'm gonna purchase the Laura Mercier SC Concealer soon, will review soon!)

If I worked out in the afternoon, I'll wash my face with The Skin Pharmacy's Deep Cleansing Amino Powder and repeat the steps above without the foundation.

PM:
Atomy Evening Deep Cleanser on dry skin to remove my makeup
Atomy Evening Care Foam Cleanser on days I wear heavier makeup or Skinlycious Anti-Acne Wash
Skinlycious Anti-Acne Solution (Dab on spots and hyperpigmentation)
Hiruscar Post-Acne Gel (On hyperpigmentation as well)
Skinlycious Hydrator Serum or The Skin Pharmacy's Hydrating Overnight Mask (which is essentially a thicker gel-like moisturiser)

Extra care:
PMD weekly
Clariancy Calla Cleanse, every night
Aztec Healing Clay Mask, depending on how my skin is feeling or Homemade Honey Mask

ALSO, I need to say this. The Aztec Indian Healing Clay Mask is amazing. I used to purchase the Anti-Acne Clay Mask from The Skin Pharmacy but stopped after I got myself a big tub of Aztec mask, which is basically 100% Calcium Bentonite. It is cheap and effective. I try to do it 3-4 times a week as I find that doing it frequently actually helps to keep my skin under control. I tried to do it less frequently but I broke out (say 1 or 2 spots, especially when the time of the month is near) more. It really does help to shrink your pores, and dry out existing acne. I had this large lump on my jaw and after dabbing the clay mask overnight for 3 days straight, it flattened itself out totally. Of course, the surrounding area will be slightly dry and also a little 'scabby' but it's definitely not an issue as it the 'scab' will fall off when your pimple recovers and it falls off when you're washing your face, so you wouldn't even notice it. It also doesn't leave any dark pigmentation!

So recently, I picked at a spot (AGAIN, bad habit I know) and ended up with a bit of a sore area which was weeping a little. I placed the clay on the area, and placed a wet gauze over it, changing it every few hours or so. The wound stopped weeping and a thin scab formed nicely over the wound. I continued for the next day and some of the scab actually fell off, leaving no harsh pigmentation.

They suggest mixing the clay with Apple Cider Vinegar, but I like that it gives room for creative recipes so you can whip up something according to your skin condition of the day. What I like to do is to substitute ACV for a bit of lemon juice (something which is acidic actually gives the clay a smoother texture and it become less chunky, thus easier to apply), add 3-4 drops of tea tree oil, 1 drop of lavender oil if I want to relax, then fill up the remaining water content with brewed green tea. If my skin is feeling extra tight that day, I'd add a dollop of honey and I'm all set.

On days when my skin feels more 'thirsty', I'll take a teaspoon for Manuka Honey, add a few drops of lemon juice (for hyperpigmentation), 2-3 drops of Tea Tree Oil, mix it up to a smooth consistency and apply it all over my face. It gets pretty messy so I like to wrap a small piece of gauze at my jaw area to prevent the honey from dripping down! I leave it on for as long as I am able to, usually 40mins-1 hour. It leaves my skin feeling nourished, and lighten any redness and pigmentation.

I'm also currently drink the Kinohimitsu BB drink! For the last month, I was drinking the J'Pan Collagen drink but switched to the BB drink as I've read that it was more suitable for oily, acne-prone skin. I find that my acne heals faster, although it won't completely prevent you from having acne. My hyperpigmentation lightens faster and my pores feel tighter. My overall skin tone looks brighter as well!

Anyway, after typing this post, I realised the woes of being a woman. I spend a fortune to make myself look better UGHS.

x
A

Biore UV Aqua Rich Watery Essence

Biore UV Aqua Rich Watery Essence


Nookery

One of the worst parts of getting older – for me – has been those delightful expression lines on my forehead that seem to get deeper with each passing year. Seriously, I must be the mos…

Zinc Oxide Sunscreens - Ageless Looks

Zinc Oxide Sunscreens - Ageless Looks


LONGECITY

Page 1 of 2 - Zinc Oxide Sunscreens - posted in Ageless Looks: I prefer to use a zinc oxide based sunscreen, and have tried several (often imported from the USA as there arent as many available in the UK). The best ones Ive found seem to include a low percentage (around 7% or so) of non-nano zinc oxide, or a higher percentage (17% or more) of nano zinc oxide. It seems that UVA1 protection is not as good with nano particles, but would that be balanced out by the higher percentage?...

Acne Help, Skinlycious Products Review

by noreply@blogger.com (Wenxuan) @ Wild Flower

I have been using The Skin Pharmacy's products for about 4 months now and although they did help ease my acne situation, I was still getting red bumps here and there, at random spots on my face. Sometimes they would transform into full blown bumps under the skin. I suspect my outbreak was caused by the rough exfoilation of the GlamGlow Tinglexfoiliate Mask and SK-II Facial Treatment Essence as pointed out by my GP. It's sad because I really loved the SK-II Facial Treatment Masks. They are sadly too rich for people with Acne-prone skin. I now stick to 'OIL-FREE' everything. Lol.


I was so helpless that I almost made an appointment at one of those famous aesthetic clinics because my friends had seen good results. People around me are starting to recommend me products and giving me that look of disdain when they see my face. 'Your face outbreak ah?', 'Your skin not good leh.' are some comments I received. I was depressed, and I cried. A LOT that is. Those words would just replay in my mind and tears would just start streaming down. I am really not exaggerating, that was how bad it was. I didn't want to go out and I was desperate for a solution. 

One day, my stars aligned and I came across the Facebook ad by Skinlycious. I know, the name doesn't sound professional and the brand is unheard of. But I was desperate and I was willing to try anything. Of course I did some background reading and checks before I placed my first order. I initially ordered their 7-in-1 Pore Refining Serum because I actually just restocked my TSP products (and they cost me a bomb). I also requested for a sample of Skinlycious' Anti-Acne Solution which they kindly added into my order. 

I received these 2 products on the 4th of March and started using them together with my TSP products. I remembered clearly that I just returned home from teaching tuition that Wednesday night and found a large painful bump growing on my chin, so I was like, 'YAY let's put Skinlycious products to the test!' I dabbed the Anti-Acne solution on the spot and followed up with a moisturiser. Woke up the next morning and realised that the bump wasn't as large and painful anymore. AMAZING. I also noticed that my face did not oil up as fast when I used the Pore Refining Serum. 

'Okay, these products might actually work.' I was excited to see the results and I dropped Jasmine, their founder, an email to ask how should I incorporate her products into my current routine as I still have a bunch of newly bought TSP products sitting in my cupboard. She suggested that I finish up my current products and switch over to their Anti-Acne bundle, which includes their Cleanser, Anti-Acne Solution and Hydrator. However, being the impatient person that I am, I decided to go ahead and purchase the products nonetheless. I received my full set on the 10th of March,

I started using the products religiously and guess what? My redness, bumps and clogged pores improved tremendously after 3 days, I am not even kidding. People around me started telling me how much better my skin has gotten. Of course I still have a bit of clogged pores around my jawline and hyperpigmentation but the acne situation as gotten under control. I only get some very tiny bumps and the larger ones subsided within a day or two. I can actually go out without makeup now and my skin looks fine. I am hoping that with continued usage, I can achieve acne-free skin!

Of course the Anti-Acne Solution IS drying and may cause some peeling, but nothing a good hydrator cant fix. My skin is very very thin and delicate and these products work well for me. When I say a major improvement, it really is. I used to go through a box of 3M Acne Patches within 3-4 days but now I only need one or two a day. SIDE NOTE: These little patches are amazing for those annoying tiny bumps! I do also dab a little Differin prescribed by my GP at night for a little extra oomph, so far my skin is holding up well.

I am really glad I found these products and for anyone of you suffering from acne, do check out Skinlycious' products. I am almost certain you'll love it as much as I do.

I know it might to too early to say this but I am certain the products really do work as I saw the transformation myself. I'll try to post some photos when I have time! Perseverance and the right products really pays off. I'm thankful that my boyfriend motivates me throughout this whole ordeal and when I get depressed, he does his best to distract me from thinking negatively. I also started doing yoga daily and it helps refresh my mind.

P.S: Not an advertorial, as I am no blogger. I'm just sharing my experience and hopefully able to help people with the same situation!

With love,
A

LongeCity and others

by @ LongeCity - Articles

A) Background


LongeCity's origins lie with a personal website: On his private page where he chronicled his engagement with life extension, Bruce Klein also maintained a private bulleting board 'home for immortals'. Soon, visitors reached a critical mass.

And then it happened: Rather than staying at that level, we transcended it together. Bruce agreed to give up his control for something greater: the 'Immortality Institute' was founded as a members-based organisation.

 

This 'big tent' approach stood the test of time: Protagonists came and went, the original founders passed on the torch. The organisation endured, because it was no longer any individuals private agenda, it became an idea, a mission, and a community. We have left the days of the founding behind. We even changed our name, but, as an acknowledgement to this first, bold step into a unique community, LongeCity still refers to its internal Members section as the 'Immortality Institute' and remains open to Members from across the globe.


Also, until this day, our history shapes how we look at working with others: we celebrate the fantastic potential that lies in each person's own initiative and seek to empower individuals to pursue exactly those projects they feel passionate about, but we also try to link, to integrate, to join together and to collaborate in a broader context for maximum effect.

 


B) Private Individuals and their efforts/websites


There are many of personal websites around of the type Bruce started with. Some are just one person's way of discovering a new field, others grow into great resources or global benefit.
The great thing about them is the freedom they give you as the author to manage them largely as you please. Downsides exist: personal websites often have limited circulation beyond a particular social sphere or topic, missing chances for cross-pollination. A lot of energy is spent on re-inventing the wheel many times over, while it could be more productively channelled into improving what is already there. Mainly, they are fickle things, and anyone with internet experience learns not to trust them remaining as they often grind to a halt or disappear as the sole author/owner gets engaged in other priorities.

 

So on balance, LongeCity aims to make it easy for people to contribute directly to a larger pool. Members can have their own webspace or blogs or fora or linklists etc. without needing to home brew. If they want control, they can have as much as possible as long as it doesn't clash with others. (1)

On the other hand, some people only tap their full potential if they feel a project is fully and entirely their own.
IF that aspect is important to you, then please, by all means, do your own thing! We would much rather let a thousand flowers bloom than no growth at all. For maximum benefit, maybe you could still cross-reference to LongeCity?  (2)


C) Other initiatives and Organisations  


Now, this is a slightly more complicated topic.(3)

LongeCity understands itself as part of a movement. As usual in any movement, there are different preferences, protagonists, perspectives, powers and priorities. On the one hand, there is a real opportunity cost associated with not combining forces. It is sometimes very difficult to wish people good luck in setting up their own initiatives when, very clearly, their creative and financial resources could be much more effectively leveraged by using existing links and mechanisms.


On the other hand, different approaches and competition are absolutely essential to ensure that as many paths for success as possible are being pursued. LongeCity does not exist for its own sake. If it was not clear that we can make a unique contribution to the greater cause, we would close down and direct everyone to other initiatives. We need to be clear about what contribution we are making, when others are doing a better job and also when we are duplicating or being duplicated and why.

 

To all similar initiatives out there: If it looks like we are doing something very similar, please lets discuss if there are ways to generate greater synergies. This may simply mean that we stay in touch, it could mean collaboration on specific projects or it might go as far that LongeCity stops doing something and leaves it to you. OR you might decide to do what you are doing as part of LongeCity.

Two things in particular, we would much prefer to collaborate on:
1) if you are doing anything that involves a forum, we would be thrilled if you could do that at LongeCity. Over the years we have seen so many forums come and go, that we really think it a great shame to reinvent the wheel time and again. We'd gladly give you all the support and 'moderation' powers to run your own forum section at LongeCity, and a suite of powerful IT tools together with a great deal of experience as well.

2) if you are blogging or writing regular articles on life extension. Again, it is a great shame to see so many fantastic contributions swept away in the winds of time, whereas they could have been archived at LongeCity. We can easily supply you with all the tools and support, in fact we might even be able to pay you a little bit of money for your efforts - and the copyright still stays with you!

In summary, we have a mission, but not a specific 'line'. Instead we want to be a 'city'- a place where people come together. A place where different 'homes' exist fruitfully together, an umbrella group and a forum for exchange.
We would like to be a 'one-stop' info point for life extension on the web, from which people can move on to pick exactly those aspects or initiatives -at LongeCity or elsewhere- that they like. Any fellow initiatives out there, please get in touch to help make that vision a reality from which everyone benefits.

 


D) Advertisers at LongeCity 


This is a slightly different topic. Anyone who visits LongeCity will not fail to notice that it attracts the attention of people who do not care much about our mission. Some come to debate, many to learn about nutrition (but not with an ultimate interest in life extension), some try to make money. To be quite frank, part of LongeCity's particular approach is to try to extract funds from these dynamics in order to re-allocate them towards the common mission. In this context, we sometimes partner with advertisers. Now, we do in fact discuss each advertiser internally and have rejected quite a few as not something we would affiliate with. However, at the end of the day the imperative is to raise money for a cause that we consider of life-saving importance. In that context we do not necessarily choose advertisers based on their own, (or their products) life-extension credentials. LongeCity does not endorse any advertisers beyond the fact that they have made a donation to the community in exchange for exposure. Advertisers never influence our policy, ever. Advertisers get banners (please click on them) -- thats it.
Having said that, advertisers featured at LongeCity very often have a real commitment to the cause- they would not have found us otherwise. When we say something nice about an advertiser, then that is NOT something they paid for but a genuine observation regarding their conduct and contribution to the cause.

 


E) Members representing LongeCity?

 

Membership of LongeCity is a strange thing: On the one hand, its a strictly in-or-out affair. On the other, Membership is just one way (and perhaps not a good one) to differentiate the 'talkers' from the 'doers'. If you are clearly a 'doer' we would probably consider you a Member of the life extension community whether you have joined the Immortality Institute or not. One way of simulating that is to give people 'points' for activities in connection with LongeCity. If you get enough points, Membership is free. Anyone who wants to join LongeCity but can't afford the (very modest) Membership donation, please get in touch, we have never denied membership to a committed peer based on inability to pay.
LongeCity is an open place. Membership as such does not entail 'vetting'.(4)

We hope that our Members conduct themselves in an exemplary manner that reflects well on the broader community at all times. But clearly, this is not always on the cards, not least because we are deliberately opening our doors to a diverse range of backgrounds and perspectives. Thus, whether someone is a Member does not mean that this person is in any way representative of our Membership or can speak on behalf of the organisation.

What about leadership? The case is not too different. Really, the only requirement to move into a leadership position at LongeCity is some tangible commitment. We don't vet people apart from a very basic appointment review and a requirement to sign the leadership agreement. Directors and certain key officers are asked for ID, but that's about it. Now, leaders *are* expected to behave in certain ways when representing LongeCity. Clearly, they owe as much to the Membership and community. But when not wearing the LongeCity hat, leaders are free to express their views and pursue their activities as they please and without any review by LongeCity. Some leaders may have gone on to do some strange things in their lives – LongeCity does not pry into a persons private affairs, successes or failures, ventures or missteps as long as it does not affect or organisation, community and mission.
If there is uncertainty whether a LongeCity leader is doing something in an official capacity, the fault is with us for allowing this ambiguity to prevail- please let us know and we'll make sure to clarify the situation.

 


F) CONCLUSION

 

The above are observations that I make from the Chair... but with the proviso that this perspective and policy might well change as time moves on – as you have seen from our history LongeCity is certainly able to evolve!
I hope the above is useful as a reference point regarding how LongeCity relates to 'others'. I also hope it has become clear that we really don't see a lot of 'others'. Anyone who shares our mission is 'one of us'. People interested in life extension are often individualists -- and any talk of a 'community' will need to take this into account. But mindful of this fact, as gently and effectively as possible, LongeCity aspires to provide a hospitable 'home' for a community, for diverse communitIES and lone travellers alike.  

 

 

 

Footnotes:

 

(1) A good example of such a compromise are forum threads: A new discussion is initiated by a 'threadstarter'. A certain amount of responsibility comes with selecting a good topic, framing it well, giving it a good exposition. It can be frustrating if people spoil 'your' thread with inappropriate remarks. On your own website, you could just remove comments at will. On LongeCity, Members can ask to become Moderators of their own threads. It should be made clear in the first post if that option is used, so that other contributors are aware of this.

 

(2) For example, did you know that you can maintain a blog externally, AND a 'mirror' blog at LongeCity? Every post you make in your own blog can be automatically imported into your LongeCity blog. Ask if you need help setting this up.

 

(3) A reference to the 'Life of Brian' may help to set the scheme in a humorous way:

 

(4) There are some conditions of membership --they are listed in our bylaws, and I shan't go into them here, but suffice it to say that it is not very difficult to join. Very few Members have ever been expelled and where that happened it was based on activities that were directly in connection with activities on the site. While Members might sometimes be rebuked or even banned from posting on our public forums, even that does not entail automatic removal of Membership.    

 

 

Adjusting Neutrophil Behavior to Enhance Stroke Recovery

by @ LongeCityNews

An emerging theme in regenerative research is the importance of the innate immune system to the mechanisms of tissue maintenance, and researchers have so far found a number of ways in which the behavior of these immune cells might potentially be adjusted in order to enhance healing. The scientific community has made initial strides with macrophages and microglia, shifting the balance of pro-inflammatory versus pro-regenerative cells, and here some of the same high level themes are observed in the response to injury of the innate immune cells known as neutrophils. It matters greatly as to whether these immune cells turn up at the point of injury in the mode of defending against intruding pathogens, or in the mode of assisting with repair; they are capable of both, but individual cells tend to be focused only on one of these at a given time.

White blood cells called neutrophils are like soldiers in your body that form in the bone marrow and at the first sign of microbial attack, head for the site of injury just as fast as they can to neutralize invading bacteria or fungi using an armament of chemical weapons. But when that injury is an intracerebral hemorrhage, which releases blood into the brain, neutrophils arrive at the point of battle only to discover that there's no infection to attack. Unless immediately removed from the brain by other immune cells, they actually cause damage and deploy an array of toxic chemicals into the brain that worsen injury.

Now researchers have discovered a way to temporarily suppress these soldiers' pro-killing effect and turn them into beneficial weapons that scavenge for toxins, potentially opening a door for a therapeutic approach to hemorrhagic stroke treatment. A hemorrhagic stroke occurs when an artery inside the brain leaks or ruptures. It is the second-most common form of stroke after ischemic stroke, has a 30 to 67 percent mortality rate and is the main cause of disabilities among adults. Because half of hemorrhagic stroke victims die within the first two days, researchers believe that deadly secondary damage, including through toxicity of iron from the breakdown of red blood cells, leads to an excess in free radicals and inflammation.

Along with carrying chemicals that could aggravate injury, neutrophils produce and release potentially beneficial molecules including lactoferrin, an iron-binding protein. At the same time the neutrophils are getting ready to attack inside the brain, the brain and spleen are releasing interleukin-27 molecules, which can signal to the neutrophils to produce more lactoferrin and thus benefit the brain as it recovers from the stroke injury. "This is one of the first discoveries showing that you can train neutrophils to act as friendly cells. We've adapted how the body already responds naturally, but it can take 12 to 18 hours for the signal to turn them from damaging neutrophils to the beneficial cells that release lactoferrin and by then, it can be too late. Treatment with lactoferrin in our models is effective in reducing brain damage after hemorrhage and we are working on a modified form of lactoferrin that could penetrate the brain better and quicker."

Link: https://www.uth.edu/media/story.htm?id=caf2ac24-bf5a-433e-aa00-e0d22ba0209b


View the full article at FightAging

Why do some turtles outlive humans?

by @ Articles

(⇒ write for LongeCity )


The oldest human recorded in modernity was Jeanne Louise Calment, she died in the age of 122 years and 164 days [1] .

There are rumors that the oldest tortoise called Adwaita (Aldabra giant tortoise) died in the age of about 250 years [2] or that it was 188-year-old radiated tortoise named Tui Malila [3] , or that the highest verified age of 177 years had Galapagos giant tortoise Harriet [4] . The oldest currently living turtle is considered to be Jonathan (Seychelles giant tortoise), estimated to be over 180 years old these days [5] . Although all aforementioned numbers are estimations, it seems these turtles were older than human supercentenarians.

All previously mentioned species are terrestrial tortoises, a group with longest lifespans among turtles. The most famous of them, well-researched Galapagos giant tortoise, was observed by Charles Darwin when he was forming his well-known theory of evolution by natural selection [6] . There is only one freshwater turtle known to be able to outlive human, it is the common snapping turtle estimated to live up to more than hundred years [7] . While being considerably less researched, recorded maximal lifespan of sea turtles is usually shorter, not exceeding 80 years, however, it is believed that the green sea turtle can live up to 100 years. [8]

It is a difficult question to answer why these reptiles can outlive us because even to determine the actual age of animals with a long lifespan is complicated – partially due to the fact that it takes such a long time to study. Furthermore, many turtles are endangered species [9] so there may not be as many organisms to hand as needed for proper statistics. Nonetheless, we can still claim that turtles are among the most long-living vertebrates on earth [10] . Why?

Firstly, turtles, like all reptiles, benefit from being ectothermic organisms. They do not maintain body temperature and thus save a lot of energy. But that also means they are less flexible: it is crucial for their lifespan to be in natural temperature environment of daily cycles with night-time temperature drop [11] . If they do not live under these conditions in captivity, metabolic pathways change and turtles die much sooner. [12]

Turtles are well-adapted in other ways: their famous shell – the carapace –is good protection against natural predators. Most of hatchling turtles with a soft shell do not survive the first year [13] . A research of natural populations of freshwater turtles showed that only one per cent of them can celebrate the twentieth birthdays, but once the adulthood is reached, mortality rate drops and remains constant throughout the rest of life [14] .

Some turtles can survive under extreme environmental conditions, such as freezing [15] or lack of oxygen for months [16] . They can even undergo hibernation and anaerobic metabolism and therefore deal with hypoxia and anoxia, it was also proposed that the same genes can play a role in longevity itself [17] and also in oxidative stress resistance [18] that further promotes longer life [19] .

Turtle’s bones and shell are used as lactate buffer lowering metabolic acidosis caused by anaerobic glycolysis during the period of lack of oxygen [20] ; [21] Their organism is protected by strong innate immunity compensating slow acquired immune reactions [22] .

Because turtles have very slow metabolism as well as growth, their bodies do not need to deal with excessive metabolic heat and byproducts as mammals [23] . Their natural diet is very simple but also necessary for their longevity. [24]

According to the evolutionary theories, staying alive is less important after menopause. Galapagos giant tortoises achieve sexual maturity late (around the age of up to forty years in the wild, and between twenty and twenty-five years of life in captivity [25] ), then staying fertile until death [26] .

The Hayflick limit is said to determine how many times a cell can divide [27] . The Hayflick limit of Galapagos giant tortoise was said to be about 110 divisions [28] , approximately twice as many as 50 of human cells [29] . Studies in this context have highlighted the importance of telomeres, the protective end sequences of chromosomes, that get shorter with each cell division [30] , can play at least a partially role in life expectancy. It was observed that telomeres in European freshwater turtle’s cells are of the same length in both embryo and adult organism [31] .

Thus, it was believed that turtles are negligibly senescent organisms [32] . In other words, the cells do not age and no age-related diseases appear, which is very different cell behavior than in human bodies [33] and probably the key to any natural longevity. However, evidence now suggests that turtles may not be really negligibly senescent because of observations of survival and reproductive senescence in late age in the painted turtle population [34]

As we can see, turtles have some advantages in the lifespan field. Some of these might inspire researchers to increase lifespans in humans.



References

[1] Oldest person ever. Retrieved January 31, 2017, from http://www.guinnessworldrecords.com/world-records/oldest-person
[2] BBC (2006, March 23). “Clive of India’s” tortoise dies. BBC South Asia. Retrieved from http://news.bbc.co.uk/2/hi/south_asia/4837988.stm
[3] Associated Press (2006, June 26). Tortoise believed to have been owned by Darwin Dies at 176. Fox News. Retrieved from http://www.foxnews.com/story/2006/06/26/tortoise-believed-to-have-been-owned-by-darwin-dies-at-176.html
[4] Galapagos tortoise (Geochelone nigra) longevity, ageing, and life history. Retrieved January 31, 2017, from http://genomics.senescence.info/species/entry.php?species=Geochelone_nigra
[5] Hollins, J. (2012). The world’s most isolated vet? Veterinary Record, 171(2), i–i. doi:10.1136/vr.g7292
[6] Powell, J., & Caccone, A. (2006). Giant tortoises. Current Biology, 16(5), R144–R145. doi:10.1016/j.cub.2006.02.050
[7] Cameron, M. (2008). COSEWIC Assessment and Status Report on the Snapping Turtle Chelydra serpentina in Canada . Retrieved from http://publications.gc.ca/collections/collection_2009/ec/CW69-14-565-2009E.pdf
[8] Green sea turtle (Chelonia mydas) longevity, ageing, and life history. Retrieved January 31, 2017, from http://genomics.senescence.info/species/entry.php?species=Chelonia_mydas
[9] Jacobson, E. R. (1994). Causes of Mortality and Diseases in Tortoises: A Review. Journal of Zoo and Wildlife Medicine, 25(1), 2–17.
[10] Gibbons, J. W. (1987). Why do turtles live so long? BioScience, 37(4), 262–269. doi:10.2307/1310589
[11] Flouris, A. D., & Piantoni, C. (2014). Links between thermoregulation and aging in endotherms and ectotherms. Temperature, 2(1), 73–85. doi:10.4161/23328940.2014.989793
[12] Vadala, N. How Long Do Turtles Live? Retrieved January 31, 2017, from http://www.petmd.com/reptile/care/how-long-do-turtles-live
[13] Stewart, K. R., & Wyneken, J. (2004). Predation risk to loggerhead hatchlings at a high-density nesting beach in Southeast Florida. Bulletin of Marine Science, 74(2), 325–335.
[14] Gibbons, J. W., & Semlitsch, R. D. (1982). Survivorship and longevity of a long-lived vertebrate species: How long do turtles live? The Journal of Animal Ecology, 51(2), 523. doi:10.2307/3981
[15] Packard, G. C., & Packard, M. J. (2003). Natural freeze-tolerance in hatchling painted turtles? Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 134(2), 233–246. doi:10.1016/s1095-6433(02)00264-7
[16] Milton, S. L., & Prentice, H. M. (2007). Beyond anoxia: The physiology of metabolic downregulation and recovery in the anoxia-tolerant turtle. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 147(2), 277–290. doi:10.1016/j.cbpa.2006.08.041
[17] Shaffer, H. B., Minx, P., Warren, D. E., Shedlock, A. M., Thomson, R. C., Valenzuela, N., … Wilson, R. K. (2013). The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage. Genome Biology, 14(3), R28.doi:10.1186/gb-2013-14-3-r28
[18] Garbarino, V. R., Orr, M. E., Rodriguez, K. A., & Buffenstein, R. (2015). Mechanisms of oxidative stress resistance in the brain: Lessons learned from hypoxia tolerant extremophilic vertebrates. Archives of Biochemistry and Biophysics, 576, 8–16. doi:10.1016/j.abb.2015.01.029
[19] von Zglinicki, T. (2002). Oxidative stress shortens telomeres. Trends in Biochemical Sciences, 27(7), 339–344. doi:10.1016/s0968-0004(02)02110-2
[20] Jackson, D. C. (2000). Living without oxygen: Lessons from the freshwater turtle. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 125(3), 299–315. doi:10.1016/s1095-6433(00)00160-4
[21] Krivoruchko & Storey, 2010).
[22] Sandmeier, F. C., Tracy, C. R., Dupre, S., & Hunter, K. (2012). A trade-off between natural and acquired antibody production in a reptile: Implications for long-term resistance to disease. Biology Open, 1(11), 1078–1082. doi:10.1242/bio.20122527
[23] Bilinski, T., Paszkiewicz, T., & Zadrag-Tecza, R. (2015). Energy excess is the main cause of accelerated aging of mammals. Oncotarget, 6(15), 12909–12919. doi:10.18632/oncotarget.4271
[24] Casares, M., Honegger, R. E., & Rubel, A. (1995). Management of giant tortoises Geochelone elephantopus and Geochelone gigantean at Zurich Zoological gardens. International Zoo Yearbook, 34(1), 135–143. doi:10.1111/j.1748-1090.1995.tb00671.x
[25] Global, S. D. Z. (2010). Galapagos tortoise fact sheet. Retrieved January 31, 2017, from http://library.sandiegozoo.org/factsheets/galapagos_tortoise/tortoise.htm
[26] Curtin, A. J., Zug, G. R., & Spotila, J. R. (2009). Longevity and growth strategies of the desert tortoise (Gopherus agassizii) in two American deserts. Journal of Arid Environments, 73(4-5), 463–471. doi:10.1016/j.jaridenv.2008.11.011
[27] Hayflick, L. (1965). The limited in vitro lifetime of human diploid cell strains. Experimental Cell Research, 37(3), 614–636. doi:10.1016/0014-4827(65)90211-9
[28] Goldstein, S. (1974). Aging in vitro. Experimental Cell Research, 83(2), 297–302. doi:10.1016/0014-4827(74)90342-5
[29] Hayflick, L., & Moorhead, P. S. (1961). The serial cultivation of human diploid cell strains. Experimental Cell Research, 25(3), 585–621. doi:10.1016/0014-4827(61)90192-6
[30] Harley, C. B., Futcher, A. B., & Greider, C. W. (1990). Telomeres shorten during ageing of human fibroblasts. Nature, 345(6274), 458–460. doi:10.1038/345458a0
[31] Girondot, M., & Garcia, J. (1999). Senescence and longevity in turtles: What telomeres tell us. 9th extraordinary meeting of the societas Europaea Herpetologica, 1, 25–29. Retrieved from //www.researchgate.net/publication/252290006_Senescence_and_longevity_in_turtles_What_telomeres_tell_us
[32] Miller, J. K. (2001). Escaping senescence: Demographic data from the three-toed box turtle (Terrapene carolina triunguis). Experimental Gerontology, 36(4-6), 829–832. doi:10.1016/s0531-5565(00)00243-6
[33] Schächter, F., Cohen, D., & Kirkwood, T. (1993). Prospects for the genetics of human longevity. Human Genetics, 91(6), . doi:10.1007/bf00205074
[34] Warner, D. A., Miller, D. A. W., Bronikowski, A. M., & Janzen, F. J. (2016). Decades of field data reveal that turtles senesce in the wild. Proceedings of the National Academy of Sciences, 113(23), 6502–6507. doi:10.1073/pnas.1600035113

Sunscreen showdown 2K16: Review of Biore, Missha, TonyMoly, Sunbears and Holika Holika Sunscreens

Sunscreen showdown 2K16: Review of Biore, Missha, TonyMoly, Sunbears and Holika Holika Sunscreens


Peepingpomeranian

Followers on my Instagram (@peepingpomeranian) and Snapchat (@peepingpompom) have already seen some of the testing and peeks at how the different sunscreens in my collection fared. But for the rest…

Kao Biore Aqua Rich Watery Mousse Water Base SPF 50+ PA+++ Review – Musings of a Muse

Kao Biore Aqua Rich Watery Mousse Water Base SPF 50+ PA+++ Review – Musings of a Muse


Musings of a Muse

SPF.... Such a chore isn't it? But a necessary evil. If you aren't SPF'ing yourself to death prior to heading out the door in the morning we can't be frien

Skincare Updates, again! (Banila & co, Q-switch Laser, Effaclar K+, My Beauty Diary Sheet Masks)

by noreply@blogger.com (Wenxuan) @ Wild Flower

It has been almost 3 months since I last checked in on my skin condition and I just reorganised my skincare items, so I thought why not take some time to do a post to keep track of my skin's progress.

Somewhere in between late May-June, I actually embarked on my first Oil Cleansing Method (OCM) regime with hemp seed oil, and tried out a minimalistic/natural skincare regime for about a month. OCM was great in the sense that I could actually feel those sebum plugs coming out when I massaged the oil all over my face. However, my face was still quite clogged and spotty. It was also very dry and I couldn't apply my foundation without having it cling on to my dry patches. Not cute, I know.

I stopped the previous regime since it wasn't working for me and got back to using Skinlycious' products again but my skin was still dry, red-looking and spotty. Ughs. It was slightly better for a while and I went off to China for 2 weeks in July. My skin was being pretty obedient for the first 2 days, then it started going wonky again right after that. My skin was drying up, I had new spots everyday that would itch like there's no tomorrow. Came back to SG, looking worse than when I left! (Major sad face)

Anyway I stumbled about the no!no! skin device on SIA's inflight shopping magazine and decided to purchase this tiny (but trust me. It's strong) Light and Heat Energy (LHE) zit zapper on my return flight. It was SGD245 and I was on the verge of giving up on my skin. Just thought hey, it sounds good so why not take the plunge and try it. As all my friends/bf/family already know, I'm a major sucker for anything that would help with my skin. No matter how pricey it would seem, if I am able to afford it, I'd try it.

I also bought Banila & Co.'s Clean It Zero (Pink-Normal) makeup cleansing balm and IT IS SERIOUSLY AMAZING. Only SGD20 at Shilla Duty Free! (Regretting right now that I didn't purchase more...) It's like oil-cleansing, but less messy and as effective. It smells great, removes make up well and sebum plugs would also come out if you massage it into your skin for at least 2 minutes. My skin has been loving it thus far, hasn't reacted negatively towards it so I'm really glad! They do have other versions of the Clean It Zero, but I chose the most basic one, just in case.

I also started Q-switch Laser Sessions at an aesthetics clinic which gave me really good results. Active pimples are healed, clogged pores and old brown marks (Post-inflammatory Hyperpigmentation, PIH) are significantly reduced. Of course it's only the first few sessions, so I still have a few brown spots on my left jaw but I can apply just a thin layer of foundation and I'm good to go. Save so much time on concealing! My pain tolerance is really quite up there, so the doctor administered higher powered shots on me. For those who can't tolerate pain very well, the doc will adjust the power level accordingly! My doctor commented that my clogged pores are more or less gone now, except for a few small bumps which is normal to get. Now it's just to focus on removing the PIH! Will update again on my Q-switch results, and I really can't wait for the progress too!

What I found that have helped was a couple of things (besides the laser). First, I'd mist my face with a Thermal Spray (currently using Uriage but have purchased La Roche Posay to try) then drop one drop of tea tree oil (TTO) on my palm and pat it in together with the thermal water. That really helps to calm down ANY irritations (read: itchiness) and it definitely does kill any horrible P.acnes bacteria on my skin. I have also started using sheet masks as the doc has commented that I actually have DRY skin (woah really?). More of like Combi/Oily - Dry on the outside, Oily inside - sort of complicated situation, hence the outbreaks pfft.

I've also made a major skincare routine overhaul after I came back from China. So here goes:

AM
Face wash: Cetaphil/Physiogel Cleanser
(Mist face with Uriage Thermal water, with one drop of TTO)
La Roche Posay Effaclar K+ - this one I'm still testing, so far so good hasn't given me any clogged pores and seem to refine my skin texture
Doctor's moisturiser
Spot treat with Vichy Hyaluspot Treatment

PM
Face wash: Simple Oil Balancing Exfoliating Wash - didn't expect to like this but it's doing a good job at keep my oil-water balance so it's a keep for now :)
Alternate between Innisfree Super Volcanic Clay Mask and Aztec Indian Healing Clay
(Mist face with Uriage Thermal Water with one drop of TTO)
MBD Sheet mask (will go into that in a bit)
Effaclar K+
Laneige Sleeping Mask
Topicals: Epiduo/Differin

Of course I'd also zap spots with the no!no! Skin device and it really helps to bring down the infection especially if it's those kinda pesky blind pimples. I might have over applied my epiduo at times, and I'd end up with slightly obvious brown spots on the spots the next day so I'm keeping that in mind. TO APPLY IT SPARINGLY. I'd apply a thin layer on areas where spots are prone to occur, then spot treat those red spots/bumps/PIH. Please do not follow my method, as the web stated to apply just a thin layer. I IZ KIASU.

My Beauty Diary Masks

This is one of the ever popular sheet mask brands out there and I'm only jumping onto the bandwagon now. I DID purchased them a few years back but felt like they didn't really do anything much for me. So far, I've tried the Imperial Bird's Nest, Aloe, Luffa and the Black Pearl Total Effects (mask sheet is black). My favourites are the Imperial Bird's Nest and Luffa!!! I've even bought a spare box of the IBN to keep because I've been masking almost daily for the past 2 weeks! Luffa was a surprise because I bought it before and it didn't seem to do anything to my skin. I was hoping that I'd love the Aloe vera one but unfortunately, it makes my face itchy and some clogged bumps would appear after :(

Yes I tried the Aloe one yesterday and it gave me the same bumps so I'm giving them away for sure. I've actually also purchased the Naruko Snail Repair Mask and they gave me bumps too! No go for these two, if you've clog-prone, acne-prone, sensitive skin like me. Although the aloe vera one had glowing reviews from redditors, it didn't work out well for me. I'm gonna try the apple phenol one next, and either stock up on the IBN or Luffa ones because Watson's and Guardian are having a 2 for SGD27 promo now!

I do need to mention I use clay masks daily too after washing my face at night, then I'd use the sheet masks after. I find that it didn't dry out my skin, but instead purified it of the impurities as I do get quite oily in the evenings. I let the clay masks sit for a shorter time if I find that my face is less oily that day! I know it might seem like a little of an overkill to some but it has worked in keeping my skin relatively clear so far. I'm planning to reduce the masks (clay & sheet) to about once every 2 days once my skin stabilises itself.

That's all I have for this update, till the next one and hopefully with great skin. Hang in there everyone who's facing a similar condition!

With love,
A

Review: The Body Shop Skin Defence Multi Protection Essence sunscreen

Review: The Body Shop Skin Defence Multi Protection Essence sunscreen


My Women Stuff

Review of The Body Shop Skin Defence sunscreen that is lightweight and non-greasy but there is something about it that just doesn't work for me

2017 Biore UV Aqua Rich Watery Essence Sunscreen Made in Japan 50g SPF50+ PA++++  | eBay

2017 Biore UV Aqua Rich Watery Essence Sunscreen Made in Japan 50g SPF50+ PA++++ | eBay


eBay

Kao Biore UV Aqua Rich Watery Essence Sunscreen. Authentic Product, Made in Japan for Japanese Market. made in Japan for sale to the Japanese market (. not cheaper versions made in or made for China/Taiwan). | eBay!

Essence Honey Care Moisturizing & Caring Hand Cream Review

by Isabella Muse @ Musings of a Muse

Essence Honey Care Moisturizing & Caring Hand Cream ($3.99) is a new honey hand cream hanging out on my desk on the moment. You might recall my review of Essence Honey Care Smoothing Nail & Cuticle Scrub last month and I mentioned how I’d love to see more products scented like this. Much to my […]

The post Essence Honey Care Moisturizing & Caring Hand Cream Review appeared first on Musings of a Muse.

Bioré appoints Hakuhodo

Bioré appoints Hakuhodo


Marketing Interactive

Japanese sunscreen brand, Bioré UV Watery Essence has appointed Hakuhodo Singapore to launch a campaign for the product.

Is glycation from exogenous ribose supplementation an issue?

by @ ImmInst Active Topics

Life extension published this article on ribose, which seems to refute the concern about glycation (over and above other carbs) please debate.

From : http://www.lifeextension.com/Magazine/2012/10/Restoring-Cellular-Energy-Metabolism/Page-02

"Fibromyalgia
Fibromyalgia (FM) and chronic fatigue syndrome are conditions that often occur together and are believed to have a similar underlying cause.28

There's accumulating evidence that defective production of ATP is the culprit.28-30 These findings make d-ribose a natural candidate as a therapy for those suffering from fibromyalgia and chronic fatigue syndrome. A published case study showed that a woman with fibromyalgia experienced a decrease in symptoms following supplementation with d-ribose.31 The patient had been unresponsive to prior medications, and her physicians based their decision on the known energy-enhancing capabilities of d-ribose.

A larger study soon followed enlisting 41 patients with fibromyalgia or chronic fatigue syndrome.28 Subjects took 5 grams of d-ribose three times daily until they reached a total of 280 grams.

There was significant improvement in all five categories on a standard score: energy, sleep, mental clarity, pain intensity, and well-being.28 On average, patients reported a 45% increase in energy levels.

While fibromyalgia and chronic fatigue syndrome remain complicated and perplexing to scientists, these findings offer real hope for a solution.

Restless Leg Syndrome
Restless Leg Syndrome
Restless leg syndrome (RLS) is a common disorder that affects as many as 15% of the US population, and it is severe enough to warrant medical treatment in more than a third of those people.32,33

The condition involves an uncontrollable urge to move the legs, accompanied by uncomfortable sensations, and it is usually worse at night.33 Only a few medications offer even partial relief of restless leg syndrome, and many make the condition worse—leaving sufferers without much recourse.32,33

Disordered energy metabolism has been suggested as one possible cause of restless leg syndrome. Low levels of adenosine, the d-ribose-containing central molecule in ATP, have been reported in those suffering from restless leg syndrome.34

Based on that observation, one study has been carried out in which daytime symptoms were eliminated, and nighttime symptoms significantly reduced, on daily doses of 15 grams of d-ribose, taken as one 5-gram dose with breakfast, lunch, and dinner.26

It's clearly too early to claim that d-ribose cures the condition, but these encouraging findings—coupled with complete absence of side effects—warrant further investigation.

UNGROUNDED FEAR: CAN D-RIBOSE CAUSE GLYCATION REACTIONS?
It is now generally accepted that d-ribose supplementation provides many health benefits, particularly in the area of cellular energy management.

Several recent publications, however, have raised the question of whether d-ribose—because it is a sugar—could possibly contribute to development of harmful advanced glycation endproducts.40-43

The truth seems to be straightforward: Like any sugar, ribose can indeed cause protein glycation, with resulting damage to tissues.42 And when ribose is administered experimentally at the same high dose as glucose, ribose quickly causes the protein cross-linking that is the outcome of glycation.40

But those studies used artificially high doses and concentrations of ribose, levels never found in humans—even after high-dose supplementation.

For example, in a human study of d-ribose supplementation at doses of 20 and 53 grams over a 4-hour period, peak serum ribose levels rose to only 4.8 mg/dL and 81.7 mg/dL, respectively.44

But doses used in the glycation experiments were significantly higher, up to 30 times higher than achievable in human blood!42,43

And in an experiment showing that d-ribose induced glycation and impaired spatial cognition in mice, the ribose concentrations used were equivalent to blood levels of 150 to 750 mg/dL, clearly vastly higher than have been used in human studies.43,44

Researchers seeking to show that ribose-induced glycation could enhance cartilage damage in an animal model of osteoarthritis showed conclusively that even direct injection of ribose into the joint was incapable of triggering sufficient glycation to cause injury!45,46

The doses for d-ribose studies reported in this article—15 to 60 grams per day in divided doses—are incapable of causing serum ribose concentrations high enough to get anywhere near the risk of excessive glycation reported in the lab studies.44

Also, most human studies recommended splitting the total amount into three daily doses; this approach provides even greater assurance that serum d-ribose remains well within safe levels.

Kidney Protection
Like the brain and heart, the human kidney receives a a high proportion of the body's total blood flow—which makes it equally vulnerable to damage by ischemia-reperfusion mechanisms, the loss and restoration of blood flow.

These kidney injuries can occur as the result of trauma or during any major surgery, sometimes worsened by chronic conditions such as cardiovascular disease and diabetes.35-37

Growing evidence suggests that an immune activation and inflammatory response following this kind of kidney injury creates the bulk of the damage, especially in those with diabetes.12,38 Adenosine, which is partly made from d-ribose, is an important regulator of kidney function, and is especially vital during times of injury.39 These observations—coupled with what we know about d-ribose as antioxidant and anti-inflammatory—have aroused considerable interest among kidney researchers.

Japanese scientists have led the way in investigating d-ribose as a kidney protector. They have found that in rats subjected to renal ischemia-reperfusion—similar to what can occur during major surgery—d-ribose significantly reduced the release of inflammatory cytokines.12 Kidney function and appearance following the injury was improved substantially.

They also showed that d-ribose reduces activation of neutrophils, the ubiquitous white blood cells that are the first to arrive at the scene of an injury but that also release toxic chemicals and oxygen radicals that can cause additional harm.11

Clearly researchers are only beginning to realize the substantial potential of d-ribose for kidney health.

Summary
D-ribose is an essential component in our bodies' cellular energy management systems. Additionally, it provides antioxidant, anti-inflammatory, and gene regulatory capabilities. Together these characteristics make it of compelling interest to forward-thinking clinicians and patients.

Supplemental d-ribose demonstrates cardioprotection—even late in the disease process when heart attacks have already occurred, and when heart failure is developing. D-ribose helps ailing heart muscle maximize its effort, and improves blood flow to oxygen-starved cardiac tissue.

D-ribose supplements are only just being explored for similar benefits in brain and kidney tissues, but recent studies offer great hope in those areas. Even perplexing conditions such as fibromyalgia and restless leg syndrome seem to be yielding to the energy-related benefits of d-ribose. •


References
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2. Kohlhaas M, Maack C. Interplay of defective excitation-contraction coupling, energy starvation, and oxidative stress in heart failure. Trends Cardiovasc Med. 2011 Apr;21(3):69-73.

3. Available at: http://naturalmedicinejournal.net/pdf/NMJ_FEB10_NP.pdf. Accessed July 23, 2012.

4. Barsotti C, Ipata PL. Pathways for alpha-D-ribose utilization for nucleobase salvage and 5-fluorouracil activation in rat brain. Biochem Pharmacol. 2002 Jan 15;63(2):117-22.

5. Omran H, McCarter D, St Cyr J, Luderitz B. D-ribose aids congestive heart failure patients. Exp Clin Cardiol. 2004 Summer;9(2):117-8.

6. Perlmutter NS, Wilson RA, Angello DA, Palac RT, Lin J, Brown BG. Ribose facilitates thallium-201 redistribution in patients with coronary artery disease. J Nucl Med. 1991 Feb;32(2):193-200.

7. Seifert JG, Subudhi AW, Fu MX, et al. The role of ribose on oxidative stress during hypoxic exercise: a pilot study. J Med Food. 2009 Jun;12(3):690-3.

8. Freeman ML, Mertens-Talcott SU, St Cyr J, Percival SS. Ribose enhances retinoic acid-induced differentiation of HL-60 cells. Nutr Res. 2008 Nov;28(11):775-82.

9. Ferrari R, Pepi P, Ferrari F, Nesta F, Benigno M, Visioli O. Metabolic derangement in ischemic heart disease and its therapeutic control. Am J Cardiol. 1998 Sep 3;82(5A):2K-13K.

10. Ferrari R, Pepi P, Ferrari F, Nesta F, Benigno M, Visioli O. Metabolic derangement in ischemic heart disease and its therapeutic control. Am J Cardiol. 1998 Sep 3;82(5A):2K-13K.

11. Sato H, Ueki M, Asaga T, Chujo K, Maekawa N. D-ribose attenuates ischemia/reperfusion-induced renal injury by reducing neutrophil activation in rats. Tohoku J Exp Med. 2009 May;218(1):35-40.

12. Nishiyama J, Ueki M, Asaga T, Chujo K, Maekawa N. Protective action of D-ribose against renal injury caused by ischemia and reperfusion in rats with transient hyperglycemia. Tohoku J Exp Med. 2009 Nov;219(3):215-22.

13. Pauly DF, Pepine CJ. D-Ribose as a supplement for cardiac energy metabolism. J Cardiovasc Pharmacol Ther. 2000 Oct;5(4):249-58.

14. Pliml W, von Arnim T, Stablein A, Hofmann H, Zimmer HG, Erdmann E. Effects of ribose on exercise-induced ischaemia in stable coronary artery disease. Lancet. 1992 Aug 29;340(8818): 507-10.

15. Kendler BS. Supplemental conditionally essential nutrients in cardiovascular disease therapy. J Cardiovasc Nurs. 2006 Jan-Feb;21(1):9-16.

16. Sinatra ST. Metabolic cardiology: an integrative strategy in the treatment of congestive heart failure. Altern Ther Health Med. 2009 May-Jun;15(3):44-52.

17. Lopaschuk GD. Treating ischemic heart disease by pharmacologically improving cardiac energy metabolism. Presse Med. 1998 Dec 12;27(39):2100-4.

18. Pauly DF, Johnson C, St Cyr JA. The benefits of ribose in cardiovascular disease. Med Hypotheses. 2003 Feb;60(2):149-51.

19. Sinatra ST. Metabolic cardiology: the missing link in cardiovascular disease. Altern Ther Health Med. 2009 Mar-Apr;15(2):48-50.

20. Hegewald MG, Palac RT, Angello DA, Perlmutter NS, Wilson RA. Ribose infusion accelerates thallium redistribution with early imaging compared with late 24-hour imaging without ribose. J Am Coll Cardiol. 1991 Dec;18(7):1671-81.

21. Omran H, Illien S, MacCarter D, St Cyr J, Luderitz B. D-Ribose improves diastolic function and quality of life in congestive heart failure patients: a prospective feasibility study. Eur J Heart Fail. 2003 Oct;5(5):615-9.

22. Omran H, McCarter D, St Cyr J, Luderitz B. D-ribose aids congestive heart failure patients. Exp Clin Cardiol. 2004 Summer;9(2):117-8.

23. Schneider HJ, Rossner S, Pfeiffer D, Hagendorff A. D-ribose improves cardiac contractility and hemodynamics, and reduces expression of c-fos in the hippocampus during sustained slow ventricular tachycardia in rats. Int J Cardiol. 2008 Mar 28;125(1):49-56.

24. Sawada SG, Lewis S, Kovacs R, et al. Evaluation of the anti-ischemic effects of D-ribose during dobutamine stress echocardiography: a pilot study. Cardiovasc Ultrasound. 2009;7:5.

25. MacCarter D, Vijay N, Washam M, Shecterle L, Sierminski H, St Cyr JA. D-ribose aids advanced ischemic heart failure patients. Int J Cardiol. 2009 Sep 11;137(1):79-80.

26. Chigrinskiy EA, Conway VD. Protective effect of D-ribose against inhibition of rats testes function at excessive exercise. Journal of Stress Physiology & Biochemistr. 2011;7(3):242-9.

27. Barsotti C, Ipata PL. Pathways for alpha-D-ribose utilization for nucleobase salvage and 5-fluorouracil activation in rat brain. Biochem Pharmacol. 2002 Jan 15;63(2):117-22.

28. Teitelbaum JE, Johnson C, St Cyr J. The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study. J Altern Complement Med. 2006 Nov;12(9):857-62.

29. Eisinger J, Plantamura A, Ayavou T. Glycolysis abnormalities in fibromyalgia. J Am Coll Nutr. 1994 Apr;13(2):144-8.

30. Le Goff P. Is fibromyalgia a muscle disorder? Joint Bone Spine. 2006 May;73(3):239-42.

31. Gebhart B, Jorgenson JA. Benefit of ribose in a patient with fibromyalgia. Pharmacotherapy. 2004 Nov;24(11):1646-8.

32. Martin CM. The mysteries of restless legs syndrome. Consult Pharm. 2007 Nov;22(11):907-24.

33. Bayard M, Avonda T, Wadzinski J. Restless legs syndrome. Am Fam Physician. 2008 Jul 15;78(2):235-40.

34. Guieu R, Sampieri F, Pouget J, Guy B, Rochat H. Adenosine in painful legs and moving toes syndrome. Clin Neuropharmacol. 1994 Oct;17(5):460-9.

35. Laisalmi-Kokki M, Pesonen E, Kokki H, et al. Potentially detrimental effects of N-acetylcysteine on renal function in knee arthroplasty. Free Radic Res. 2009 Jul;43(7):691-6.

36. Siems W, Quast S, Carluccio F, et al. Oxidative stress in chronic renal failure as a cardiovascular risk factor. Clin Nephrol. 2002 Jul;58 Suppl 1:S12-9.

37. Yan SF, Ramasamy R, Schmidt AM. The receptor for advanced glycation endproducts (RAGE) and cardiovascular disease. Expert Rev Mol Med. 2009;11:e9.

38. Jang HR, Ko GJ, Wasowska BA, Rabb H. The interaction between ischemia-reperfusion and immune responses in the kidney. J Mol Med. 2009 Sep;87(9):859-64.

39. Vallon V, Osswald H. Adenosine receptors and the kidney. Handb Exp Pharmacol. 2009 (193):443-70.

40. Mentink CJ, Hendriks M, Levels AA, Wolffenbuttel BH. Glucose-mediated cross-linking of collagen in rat tendon and skin. Clin Chim Acta. 2002 Jul;321(1-2):69-76.

41. Kuo TY, Huang CL, Yang JM, et al. The role of ribosylated-BSA in regulating PC12 cell viability. Cell Biol Toxicol. 2012 Aug;28(4): 255-67.

42. Wei Y, Han CS, Zhou J, Liu Y, Chen L, He RQ. d-ribose in glycation and protein aggregation. Biochim Biophys Acta. 2012 Apr;1820(4):488-94.

43. Han C, Lu Y, Wei Y, Liu Y, He R. D-ribose induces cellular protein glycation and impairs mouse spatial cognition. PLoS One. 2011;6(9):e24623.

44. Gross M, Zollner N. Serum levels of glucose, insulin, and C-peptide during long-term D-ribose administration in man. Klin Wochenschr. 1991 Jan 4;69(1):31-6.

45. Vos PA, Degroot J, Barten-van Rijbroek AD, et al. Elevation of cartilage AGEs does not accelerate initiation of canine experimental osteoarthritis upon mild surgical damage. J Orthop Res. 2012 Mar 2.

46. Willett TL, Kandel R, De Croos JN, Avery NC, Grynpas MD. Enhanced levels of non-enzymatic glycation and pentosidine crosslinking in spontaneous osteoarthritis progression. Osteoarthritis Cartilage. 2012 Jul;20(7):736-44."

Benjamin Law: 'What do I want to smell like? I feel like I’ve just nailed it'

Benjamin Law: 'What do I want to smell like? I feel like I’ve just nailed it'


the Guardian

The author discusses his hatred of Lynx Africa deodorant, his enduring affection for David Sedaris and why the smell of Dettol reminds him of childhood

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Pendapat kamu tentang cewe yg Oplas?

by lyra @ Female Daily Forum

Sejak era k-pop dan Kylie Jenner.. Di mana kita melihat hasil2 oplas yg sukses.. Kini berbondong2 orang kepengen oplas biar makin cantik. Begitu...

Sunscreen Round Up and Comparison! (Biore, Missha, Vichy)

Sunscreen Round Up and Comparison! (Biore, Missha, Vichy)


Twenty Swans

You know what? I recently did a review and mentioned how I was not into skincare as much as I usually am, and now I am on it again, scouring skincare instead of makeup online. This was unexpected. …

SK II Facial Treatment Mask Review

by noreply@blogger.com (Wenxuan) @ Wild Flower

Omg I literally just used the SK-II Facial Treatment Mask just an hour ago after I cleansed my face, and here I am, an hour later, penning down my review. THAT IS HOW MUCH I LOVE IT.

During the recent Luxola sale, I jumped on the chance to get my hands on the Pitera Essence Set which consists of: a 75ml SK-II FTE, 30ml Facial Clear Lotion and a piece of Facial Treatment Mask. All for SGD99 before discount! It's a really good deal as a 75ml SK-II FTE already cost SGD99 on its own. Okay so no pictures of the me or the product as I excitedly ripped open the box upon receiving my item, and excitedly ripped off the package to use the mask.

Honestly, I had 0 expectations for the mask because after using the FTE for close to a week, I didn't see any obvious change to my skin texture, perhaps just slightly more hydrated. I just did my usual routine and slapped on some GlamGlow Youth Mud for 10 mins, use my Alpha H Liquid Gold to tone my skin, then applied the SK-II mask as instructed. Firstly, I must say that the cotton mask is thick and of high quality and the essence contained in the packet is sooo generous. It fits my face shape really well too! And I usually have some problems with face masks because they usually don't fit my face shape very well... so I am very impressed. I think I left it on for about 20 mins because there was so much essence that is too precious to be wasted! There was also a good amount left in the packet so I put in my low quality face mask (sobs) that doesn't really fit my face, sealed it up and put it back in the fridge, ready for a second use.

What won me over was the effect after just a mere 20 mins. My face was clearly well hydrated from within, very plumped up (boing boing), somewhat lifted and very dewy! I patted the remaining essence into my face and my skin felt very nice to touch. I had a few blind pimples that grew over the week, and although they have flattened and popped on their own, there was still some pigmentation and redness :( But my face was very refreshed and the redness became only very minimal. There was still a lot of essence absorbed in the mask so I squeeze those out and applied it all over my neck, arms and thighs!

I cannot emphasise how much I love it. I proceeded to tell all my friends how the mask was the bomb and if anyone is going to get anything from SK-II, this is a must. What else can I say but I AM SOLD! SK-II TAKE ALL MY MONEY!

I rarely use or rave about facial masks because I don't usually experience any miracles with them and I'm already contemplating on getting the 6 or 10 pc pack, that is how much I love it. I supposed you're able to get about 2 usages out of 1 pack if you have additional blank cotton face masks at home. If you're actually hesitating on whether you should get this, hesitate no further! Run out and get it now! Or if you're wondering which SK-II product should you invest in (and you already have a skincare routine that you love), I would highly recommend this as it is a really good perk-me-up for the skin!

Till next time,
A

ChitChat Cerita Ke-bokek-an

by fourstarmary @ Female Daily Forum

Mari berbagi cerita2 masa2 bokek. Growing up, keluarga gue selalu struggling with money. Tapi gue bersyukur at least gue ga pernah harus makan...

Menangkan Produk Kecantikan Senilai 10 Juta Rupiah di Blushing September Giveaway

by puisisi @ Female Daily Forum

Hi, Beauty Enthusiast! Good news untuk kamu yang rajin tulis Beauty Review, bulan September ini Female Daily kembali mengadakan Beauty Review...

Contest Dapatkan Voucher Belanja di In The Now Contest!

by puisisi @ Female Daily Forum

Hi, Ladies! Di sini siapa yang setuju kalau hidup itu harus ada target setiap tahunnya? Aku sendiri selalu menargetkan diri untuk ngelakuin hal...

Biore UV Aqua Rich Watery Essence Sunscreen SPF50+ PA+++ Review

Biore UV Aqua Rich Watery Essence Sunscreen SPF50+ PA+++ Review


Makeupandbeauty.com

Biore UV Aqua Rich Watery Essence Sunscreen SPF50+ PA+++ I apply ¼ tablespoon of this sunscreen after my moisturizer.

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Review: Biore UV Aqua Rich Watery Essence Face Sunscreen SPF 50/ PA+++

Review: Biore UV Aqua Rich Watery Essence Face Sunscreen SPF 50/ PA+++


Skin & Tonics : A Skincare Blog

The first time I used Biore UV Aqua Rich Watery Essence Sunscreen, my immediate thought was, “Oh good, the perfect sunscreen! Sunscreen chemists, you can all go home now. Nice job, everyone!” Then …

Biore UV Sunscreens • £9.73

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Biore UV Sunscreens FOR SALE • £9.73 • See Photos! Money Back Guarantee. Biore UV Sunscreens ITEM DESCRIPTION· Biore UV Aqua Rich is a Japanese drugstore sunscreen line for daily use that features protection-enriched Water Capsule that enables the sunscreen to turn into 162310007848

Fermented Skincare: A Review of Whamisa Organic Flowers Deep Rich Essence Toner

by Kerry @ Skin & Tonics : A Skincare Blog

I want you to know that I’m cracking my knuckles right now, in preparation for typing up this review. It’s a long one, but it’s good, and I’ve been looking forward to writing about this product for a while! If you’re into skincare that is both glamorous and highly functional, get ready to be excited, […]

The post Fermented Skincare: A Review of Whamisa Organic Flowers Deep Rich Essence Toner appeared first on Skin & Tonics : A Skincare Blog.

Sunscreens For Rosacea Sensitive Skin - Talonted Lex

Sunscreens For Rosacea Sensitive Skin - Talonted Lex


talonted lex

Sunscreens For Rosacea Sensitive Skin - It's tricky to find a sunscreen that works but won't aggravate my reactive skin. Hear my 7 recommendations here.

Why do some turtles outlive humans?

by @ Articles - Articles

(⇒ write for LongeCity )


The oldest human recorded in modernity was Jeanne Louise Calment, she died in the age of 122 years and 164 days [1] .

There are rumors that the oldest tortoise called Adwaita (Aldabra giant tortoise) died in the age of about 250 years [2] or that it was 188-year-old radiated tortoise named Tui Malila [3] , or that the highest verified age of 177 years had Galapagos giant tortoise Harriet [4] . The oldest currently living turtle is considered to be Jonathan (Seychelles giant tortoise), estimated to be over 180 years old these days [5] . Although all aforementioned numbers are estimations, it seems these turtles were older than human supercentenarians.

All previously mentioned species are terrestrial tortoises, a group with longest lifespans among turtles. The most famous of them, well-researched Galapagos giant tortoise, was observed by Charles Darwin when he was forming his well-known theory of evolution by natural selection [6] . There is only one freshwater turtle known to be able to outlive human, it is the common snapping turtle estimated to live up to more than hundred years [7] . While being considerably less researched, recorded maximal lifespan of sea turtles is usually shorter, not exceeding 80 years, however, it is believed that the green sea turtle can live up to 100 years. [8]

It is a difficult question to answer why these reptiles can outlive us because even to determine the actual age of animals with a long lifespan is complicated – partially due to the fact that it takes such a long time to study. Furthermore, many turtles are endangered species [9] so there may not be as many organisms to hand as needed for proper statistics. Nonetheless, we can still claim that turtles are among the most long-living vertebrates on earth [10] . Why?

Firstly, turtles, like all reptiles, benefit from being ectothermic organisms. They do not maintain body temperature and thus save a lot of energy. But that also means they are less flexible: it is crucial for their lifespan to be in natural temperature environment of daily cycles with night-time temperature drop [11] . If they do not live under these conditions in captivity, metabolic pathways change and turtles die much sooner. [12]

Turtles are well-adapted in other ways: their famous shell – the carapace –is good protection against natural predators. Most of hatchling turtles with a soft shell do not survive the first year [13] . A research of natural populations of freshwater turtles showed that only one per cent of them can celebrate the twentieth birthdays, but once the adulthood is reached, mortality rate drops and remains constant throughout the rest of life [14] .

Some turtles can survive under extreme environmental conditions, such as freezing [15] or lack of oxygen for months [16] . They can even undergo hibernation and anaerobic metabolism and therefore deal with hypoxia and anoxia, it was also proposed that the same genes can play a role in longevity itself [17] and also in oxidative stress resistance [18] that further promotes longer life [19] .

Turtle’s bones and shell are used as lactate buffer lowering metabolic acidosis caused by anaerobic glycolysis during the period of lack of oxygen [20] ; [21] Their organism is protected by strong innate immunity compensating slow acquired immune reactions [22] .

Because turtles have very slow metabolism as well as growth, their bodies do not need to deal with excessive metabolic heat and byproducts as mammals [23] . Their natural diet is very simple but also necessary for their longevity. [24]

According to the evolutionary theories, staying alive is less important after menopause. Galapagos giant tortoises achieve sexual maturity late (around the age of up to forty years in the wild, and between twenty and twenty-five years of life in captivity [25] ), then staying fertile until death [26] .

The Hayflick limit is said to determine how many times a cell can divide [27] . The Hayflick limit of Galapagos giant tortoise was said to be about 110 divisions [28] , approximately twice as many as 50 of human cells [29] . Studies in this context have highlighted the importance of telomeres, the protective end sequences of chromosomes, that get shorter with each cell division [30] , can play at least a partially role in life expectancy. It was observed that telomeres in European freshwater turtle’s cells are of the same length in both embryo and adult organism [31] .

Thus, it was believed that turtles are negligibly senescent organisms [32] . In other words, the cells do not age and no age-related diseases appear, which is very different cell behavior than in human bodies [33] and probably the key to any natural longevity. However, evidence now suggests that turtles may not be really negligibly senescent because of observations of survival and reproductive senescence in late age in the painted turtle population [34]

As we can see, turtles have some advantages in the lifespan field. Some of these might inspire researchers to increase lifespans in humans.



References

[1] Oldest person ever. Retrieved January 31, 2017, from http://www.guinnessworldrecords.com/world-records/oldest-person
[2] BBC (2006, March 23). “Clive of India’s” tortoise dies. BBC South Asia. Retrieved from http://news.bbc.co.uk/2/hi/south_asia/4837988.stm
[3] Associated Press (2006, June 26). Tortoise believed to have been owned by Darwin Dies at 176. Fox News. Retrieved from http://www.foxnews.com/story/2006/06/26/tortoise-believed-to-have-been-owned-by-darwin-dies-at-176.html
[4] Galapagos tortoise (Geochelone nigra) longevity, ageing, and life history. Retrieved January 31, 2017, from http://genomics.senescence.info/species/entry.php?species=Geochelone_nigra
[5] Hollins, J. (2012). The world’s most isolated vet? Veterinary Record, 171(2), i–i. doi:10.1136/vr.g7292
[6] Powell, J., & Caccone, A. (2006). Giant tortoises. Current Biology, 16(5), R144–R145. doi:10.1016/j.cub.2006.02.050
[7] Cameron, M. (2008). COSEWIC Assessment and Status Report on the Snapping Turtle Chelydra serpentina in Canada . Retrieved from http://publications.gc.ca/collections/collection_2009/ec/CW69-14-565-2009E.pdf
[8] Green sea turtle (Chelonia mydas) longevity, ageing, and life history. Retrieved January 31, 2017, from http://genomics.senescence.info/species/entry.php?species=Chelonia_mydas
[9] Jacobson, E. R. (1994). Causes of Mortality and Diseases in Tortoises: A Review. Journal of Zoo and Wildlife Medicine, 25(1), 2–17.
[10] Gibbons, J. W. (1987). Why do turtles live so long? BioScience, 37(4), 262–269. doi:10.2307/1310589
[11] Flouris, A. D., & Piantoni, C. (2014). Links between thermoregulation and aging in endotherms and ectotherms. Temperature, 2(1), 73–85. doi:10.4161/23328940.2014.989793
[12] Vadala, N. How Long Do Turtles Live? Retrieved January 31, 2017, from http://www.petmd.com/reptile/care/how-long-do-turtles-live
[13] Stewart, K. R., & Wyneken, J. (2004). Predation risk to loggerhead hatchlings at a high-density nesting beach in Southeast Florida. Bulletin of Marine Science, 74(2), 325–335.
[14] Gibbons, J. W., & Semlitsch, R. D. (1982). Survivorship and longevity of a long-lived vertebrate species: How long do turtles live? The Journal of Animal Ecology, 51(2), 523. doi:10.2307/3981
[15] Packard, G. C., & Packard, M. J. (2003). Natural freeze-tolerance in hatchling painted turtles? Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 134(2), 233–246. doi:10.1016/s1095-6433(02)00264-7
[16] Milton, S. L., & Prentice, H. M. (2007). Beyond anoxia: The physiology of metabolic downregulation and recovery in the anoxia-tolerant turtle. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 147(2), 277–290. doi:10.1016/j.cbpa.2006.08.041
[17] Shaffer, H. B., Minx, P., Warren, D. E., Shedlock, A. M., Thomson, R. C., Valenzuela, N., … Wilson, R. K. (2013). The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage. Genome Biology, 14(3), R28.doi:10.1186/gb-2013-14-3-r28
[18] Garbarino, V. R., Orr, M. E., Rodriguez, K. A., & Buffenstein, R. (2015). Mechanisms of oxidative stress resistance in the brain: Lessons learned from hypoxia tolerant extremophilic vertebrates. Archives of Biochemistry and Biophysics, 576, 8–16. doi:10.1016/j.abb.2015.01.029
[19] von Zglinicki, T. (2002). Oxidative stress shortens telomeres. Trends in Biochemical Sciences, 27(7), 339–344. doi:10.1016/s0968-0004(02)02110-2
[20] Jackson, D. C. (2000). Living without oxygen: Lessons from the freshwater turtle. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 125(3), 299–315. doi:10.1016/s1095-6433(00)00160-4
[21] Krivoruchko & Storey, 2010).
[22] Sandmeier, F. C., Tracy, C. R., Dupre, S., & Hunter, K. (2012). A trade-off between natural and acquired antibody production in a reptile: Implications for long-term resistance to disease. Biology Open, 1(11), 1078–1082. doi:10.1242/bio.20122527
[23] Bilinski, T., Paszkiewicz, T., & Zadrag-Tecza, R. (2015). Energy excess is the main cause of accelerated aging of mammals. Oncotarget, 6(15), 12909–12919. doi:10.18632/oncotarget.4271
[24] Casares, M., Honegger, R. E., & Rubel, A. (1995). Management of giant tortoises Geochelone elephantopus and Geochelone gigantean at Zurich Zoological gardens. International Zoo Yearbook, 34(1), 135–143. doi:10.1111/j.1748-1090.1995.tb00671.x
[25] Global, S. D. Z. (2010). Galapagos tortoise fact sheet. Retrieved January 31, 2017, from http://library.sandiegozoo.org/factsheets/galapagos_tortoise/tortoise.htm
[26] Curtin, A. J., Zug, G. R., & Spotila, J. R. (2009). Longevity and growth strategies of the desert tortoise (Gopherus agassizii) in two American deserts. Journal of Arid Environments, 73(4-5), 463–471. doi:10.1016/j.jaridenv.2008.11.011
[27] Hayflick, L. (1965). The limited in vitro lifetime of human diploid cell strains. Experimental Cell Research, 37(3), 614–636. doi:10.1016/0014-4827(65)90211-9
[28] Goldstein, S. (1974). Aging in vitro. Experimental Cell Research, 83(2), 297–302. doi:10.1016/0014-4827(74)90342-5
[29] Hayflick, L., & Moorhead, P. S. (1961). The serial cultivation of human diploid cell strains. Experimental Cell Research, 25(3), 585–621. doi:10.1016/0014-4827(61)90192-6
[30] Harley, C. B., Futcher, A. B., & Greider, C. W. (1990). Telomeres shorten during ageing of human fibroblasts. Nature, 345(6274), 458–460. doi:10.1038/345458a0
[31] Girondot, M., & Garcia, J. (1999). Senescence and longevity in turtles: What telomeres tell us. 9th extraordinary meeting of the societas Europaea Herpetologica, 1, 25–29. Retrieved from //www.researchgate.net/publication/252290006_Senescence_and_longevity_in_turtles_What_telomeres_tell_us
[32] Miller, J. K. (2001). Escaping senescence: Demographic data from the three-toed box turtle (Terrapene carolina triunguis). Experimental Gerontology, 36(4-6), 829–832. doi:10.1016/s0531-5565(00)00243-6
[33] Schächter, F., Cohen, D., & Kirkwood, T. (1993). Prospects for the genetics of human longevity. Human Genetics, 91(6), . doi:10.1007/bf00205074
[34] Warner, D. A., Miller, D. A. W., Bronikowski, A. M., & Janzen, F. J. (2016). Decades of field data reveal that turtles senesce in the wild. Proceedings of the National Academy of Sciences, 113(23), 6502–6507. doi:10.1073/pnas.1600035113

Biore ads buy & sell used - find great deals and prices

Biore ads buy & sell used - find great deals and prices


Dealry Today!

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Carte D'Or Gelato from the UK to the Philippines - Animetric's World

Carte D'Or Gelato from the UK to the Philippines - Animetric's World


Animetric's World

Ever wanted to learn how to make gelato? Well, we got to attend a gelato masterclass thanks to premiere

Supplement Use and Analytics Made Simple (and Free)

by @ ImmInst Active Topics

Hi - I made this analytics engine and posted it here about two months back. The reaction was lukewarm, so I took it as I should refine it better. I took all the feedback I got from online communities and added a bunch of new features during that time. I'd love to show it off again! If you already saw it before, here's what new since then
 
- rolling correlated aggregations. IE. Want to see how a week of taking piracetam compares with a week without taking piracetam? Now you can!
- automatic sleep correlations
- fitbit integration
- better exporting of all your data (I made a promise to not hold any data hostage)
- an electronic calendar that lets you select any day and see what supplements you took during that day. So imagine three months from now, you want to know what you took on 9/22? Now you can with exact timestamps.
 
https://imgur.com/a/jXyhJ - An imgur album showing you the features
 
the link is @ https://betterself.io
 
Would love any feedback again.
 
Thanks!
Jeff

LongeCity Affiliate Labs

by @ LongeCity - Articles

The Longecity “Affiliate Labs” are small, research-focused enterprises or independent academic research groups led by a scientists with strong ties to the Longecity community and a proven track record of commitment to scientific inquiry directly relevant to the Longecity mission.
These leaders and their colleagues are not just trailblazers in advancing important areas of regenerative and rejuvenation research, but also incredibly helpful when there is a community need for peer review, when providing advice and training to a young scientist, and in providing the expertise and tools to test the novel, controversial, or promising scientific leads sourced from the Longecity community and beyond.

Community Funding
There is a small support fund that the labs can draw on to flexibly support their research activities. While not a substitute for private investment and public sector grants, the ability to flexibly ‘just try’ out a new idea without needing to ‘pitch’ in lengthy proposals can be an invaluable accelerator to research progress. All Affiliates have an active link to the Longecity community, so there is a level of accountability and responsiveness beyond anything encountered in ‘traditional’ research donations.
By donating to the Affiliate Labs fund, Members can be assured that every penny goes directly to an expert personally and professionally committed to making a difference in the scientific conquest of death.
Donate HERE

Current Affiliate Labs
- Alexandra Stolzing, Loughborough University, UK & Leipzig University, Germany.
- João Pedro de Magalhães, University of Liverpool, UK
- Kelsey Moody, Ichor Therapeutics, USA.
- Kevin Perrott – Buck Institute, USA
- Matthew O’Connor – SENS Foundation, USA

Brand FENTY Beauty by Rihanna

by fourstarmary @ Female Daily Forum

FENTY Beauty by Rihanna barusan launched and sekarang lg hyped banget. Reviews-nya mayan positif, terutama untuk foundation-nya yg sampe 40 shades....

Bioré UV Watery Essence campaign showcases light texture

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Products for Fair Skin | Chanel UV ESSENTIEL Daily Multi-Protection Facial Sunscreen SPF50+ ⋆ Forever Amber | UK fashion, lifestyle and pregnancy blog

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Forever Amber | UK fashion, lifestyle and pregnancy blog

A few weeks ago I talked a bit about how a good sunscreen is worth its weight in gold (which is almost how much this one cost, funnily enough!), so today I thought I'd show you the product I'm using at the moment, which is Chanel's UV Essentiel Daily UV Care in SPF50+. Now, it would be wrong of m

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Biorè UV, Japan's #1 Sunscreen Brand, Now Here in PH

Biorè UV, Japan's #1 Sunscreen Brand, Now Here in PH


Purple Pieces

Biore UV, the #1 sunscreen brand in Japan, is now here in the Philippines -- just in time for the summer season. Biore UV has 2 series to choose from, the Aqua Rich Series and the Perfect Series.

Review: The New 2015 Biore UV Aqua Rich Watery Essence SPF 50+ PA++++!!!!

Review: The New 2015 Biore UV Aqua Rich Watery Essence SPF 50+ PA++++!!!!


Fifty Shades of Snail

Guys, I have an announcement. I’m engaged! Yes, that’s right. The new 2015 Biore UV Aqua Rich Watery Essence sunscreen and I plan to elope soon. We will make our lifelong commit to each…

LongeCity Affiliate Labs

by @ Articles

The Longecity “Affiliate Labs” are small, research-focused enterprises or independent academic research groups led by a scientists with strong ties to the Longecity community and a proven track record of commitment to scientific inquiry directly relevant to the Longecity mission.
These leaders and their colleagues are not just trailblazers in advancing important areas of regenerative and rejuvenation research, but also incredibly helpful when there is a community need for peer review, when providing advice and training to a young scientist, and in providing the expertise and tools to test the novel, controversial, or promising scientific leads sourced from the Longecity community and beyond.

Community Funding
There is a small support fund that the labs can draw on to flexibly support their research activities. While not a substitute for private investment and public sector grants, the ability to flexibly ‘just try’ out a new idea without needing to ‘pitch’ in lengthy proposals can be an invaluable accelerator to research progress. All Affiliates have an active link to the Longecity community, so there is a level of accountability and responsiveness beyond anything encountered in ‘traditional’ research donations.
By donating to the Affiliate Labs fund, Members can be assured that every penny goes directly to an expert personally and professionally committed to making a difference in the scientific conquest of death.
Donate HERE

Current Affiliate Labs
- Alexandra Stolzing, Loughborough University, UK & Leipzig University, Germany.
- João Pedro de Magalhães, University of Liverpool, UK
- Kelsey Moody, Ichor Therapeutics, USA.
- Kevin Perrott – Buck Institute, USA
- Matthew O’Connor – SENS Foundation, USA

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Biore Deep Pore Charcoal Cleanser, 6.77 Ounce, 2 Pack
$20.99
Biore Sarasara Uv Aqua Rich Waterly Essence Sunscreen 50g Spf50+ Pa+++ for Face and Body
$9.08
BIORE Kao Foaming Face Wash, Marshmallow Whip, 5.07 Fluid Ounce
$9.60
Biore UV Aqua Rich Watery Essence SPF50+/PA++++ 50g / 1.75oz ( set of 2 )
$22.98
Biore Sarasara UV Mild Care Milk Sunscreen SPF 28 Pa++ for Face and Body, 4.05 Fluid Ounce
$8.48
KAO Biore Smooth UV Perfect Milk Spf 50 + Pa++++ 40 Ml (Sunscreen)
$8.64
Biore Charcoal Gift Pack
$12.98
Biore Charcoal Acne Clearing Cleanser 6.77 Ounce Pump (200ml) (2 Pack)
$23.96
KAO Biore Smooth UV Perfect Light Milk SPF 50 + PA++++ 40 ml
$7.24
Biore AQUA Rich Watery Essence SPF50+/PA++++ 50g + Daily Mask 365 (2sheet)
$12.99
Bioré Men's Kao Double Scrub Face Wash, 130 g
$11.08
Kao Biore | Facial Washing Foam | Acne Care 130g
$6.97
Shiseido Senka Aging Care UV Sunscreen SPF50+ PA++++
$7.55
BIORE Kao Nose Pore Clear Pack Black
$7.90
Nivea Sun Protect Super Water Gel SPF 50/PA+++ (Face & Body)Pump Type 140 g (Japan Import)
$16.99
Mens Biore Black Cleansing Nose Strips, (10 Pore Strips), (Thailand Edition)
$10.99
Mens Biore Face Lotion - UV Milk Type
$9.80
Biore Uv Perfect Silky Bright Milk Spf50 + / Pa ++++ 30ml 2015 New Packaging By 21st Century Japan
$8.99
Kao Biore | Make-up Remover | Mild Cleansing Liquid 230ml
$13.98
Biore Pore Penetrating Charcoal Bar, 3.77 Ounce (Pack of 2)
Biore Combo Pack Deep Cleansing Pore Strips Face/Nose 14 Each (Pack of 3)
$32.95
Biore Make Mo Otoseru Facial Washing Foam Uru Uru Micchaku-Awa 140ml Refill (Japan Import)
$7.31
Biore Make-up Remover Perfect Oil 230ml (Japan Import)
$14.12
Biore SARASARA UV Aqua Rich Whitening Cream Sunscreen 33g SPF50+ PA+++ for Face
$13.89
Biore Marshmallow Whip Facial Washing Foam Rich Type 150ml (Japan Import)
$8.73
Biore Skin Boosting Night Serum 1.4 fl oz (41 ml)
$19.95
Biore Daily Deep Pore Cleansing Cloths 60 Count (2 Pack)
$23.08
Biore sarasara UV Perfect Face Milk Sunscreen 30ml. SPF50 + PA+++ for Face
$14.26
Biore Uv Aqua Rich Silky Bb Essence Spf50 + / Pa ++++ 33g 2015 Packaging By 21st Century Japan Only
$7.83
MEDca Deep Cleansing Pore Strips Combo Pack, 48 Count Strips
$16.99
Biore Deep Cleansing Pore Strips, Charcoal, 6 Count (Pack of 2)
$14.89
Biore Marshmallow Whip Facial Washing Foam Rich Type - Refill 130ml
$8.36
Bioré Kao Men's Pore Cleaning Pack, Black, 0.5 lb.
$7.90
Biore Facial Washing Foam Scrub-in - 130g
$7.50
Biore Kao Biore Makeup Cleansing Sheet with Oil, 44 Count
$11.53
Garnier SkinActive Micellar Cleansing Water, All Skin Types, 13.5 fl. oz.
$8.99
Biore Uv Aqua Rich Smooth Watery Gel SPF50 + PA ++++ (2017 Summer Limited Edition)
$21.69
Biore Hard Days Night Overnight Face Moisturizer - 1.7 oz
$13.49
Biore UV Aqua Rich Watery Essence SPF50+/PA++++ 85g 2017 spring limited Edition
$18.57
BIORE U Body Angel Rose Soap Refill, 0.32 Pound
$9.99
BIORE Kao Face Cleansing Rich Moisture
$6.96
BIORE Kao Moisturizing Eye Pack
$17.99
BIORE MENS Kao Deep Oil Clear Face Wash, 130 Gram
$11.08
Biore Daily Deep Pore Cleansing Cloths 60 Count (3 Pack)
$31.98
Biore Charcoal Acne Scrub 4.5 Ounce (133ml) (2 Pack)
$20.52
Biore Kao Makeup Removing Cotton Sheet Box, 46 Count
$14.68
Biore Uv Aqua Rich Watery Cream Whitening SPF 50+/pa+++
$17.88
BIORE Kao Nose Pore Clear Pack 04
$12.99
Biore SARASARA UV Bright Face Milk BIHADA Sunscreen 30ml SPF50+ PA+++ for Face
$15.40
Biore Acne Clearing Scrub (1% Salicylic Acid), 4.5 Ounce
$6.49
Biore Moisture Jerry Very Moist Body 180ml
$11.61
Kao Biore murmuring [refill] Powder sheet Pure fresh citrus scent (36 pieces)
$8.87
Kao Japan Biore Uv Aqua Rich Watery Gel 90ml Spf30
BIORE UV Aqua Rich Watery Essence - SPF50 PA++ 50ml
$16.18
Biore Shine Control Oil Blotting Sheets Absorbs & Mattifies - 65 Sheets
$5.98
Biore Make Mo Otoseru Facial Washing Foam TSURU SUBE Bihada 210g (Japan Import)
$9.03
BIORE Aqua Rich Waterly Essence Sunscreen SPF50+ PA++++ 50g NEW-2015 (2packs)
Kao Men's Biore Bubble Facial Wash 150ml
$8.22
Biore Deep Cleansing Pore Nose Strips Charcoal 6 Count (2 Pack)
$17.89
Biore Marshmallow Whip Facial Washing Foam - Refill 130ml
$8.90
Biore Makeup Remover For Eye & Lip Active Cleansing Liquid 130Ml
$25.00
Biore Uv Aqua Rich Smooth Watery Gel Spf50 + / Pa ++++ 90ml Pack of 2
$22.79
Biore Facial Washing Foam Moisture - 130g
$8.45
Biore Charcoal Acne Clearing Cleanser 6.77 Ounce Pump (200ml) (3 Pack)
$27.13
[2017 Limited Edition] Biore UV Aqua Rich Watery Essence SPF50+/PA++++ 50g and Facial Sheet Mask (2sheet)
Biore UV Aqua Rich Watery Jelly Water Base Sunscreen for Face and Body SPF 30 90ml (3 oz)
$14.03
Biore Make Mo Otoseru Facial Washing Foam Pump 200ml (Japan Import)
$11.88
Biore Uv Aqua Rich Smooth Watery Gel Spf50 + / Pa ++++ 90ml 2015 New Version By 21st Century Japan Export by Kao Corporation
$11.97
380ml refill Men's Biore Deodorant Body Wash fresh mint scent of
$10.78
Biore Warming Anti-Blackhead Cream Face Cleanser, 4.5 oz
$7.45
Kao Men's Biore Medicinal Deodorant Body Wash fresh mint aroma of [body] (440mL) by Biore Japan
$17.97
KAO Biore Uv Perfect Face Milk Spf+50 Pa+++
$13.99
Biore U Bodywash - Fresh Floral Scented - Refill 400ml
$17.69
Mens Biore Face Lotion - Gel Type
$9.66
BIORE U Body White Floral Regular Soap, 0.32 Pound
$9.99
Biore Self Heating One Minute Mask 4 Count (2 Pack)
$16.66
Biore Sarasara UV Aqua Rich Watery Essence Sunscreen SPF50+ PA++++ 50g / COOL (2016 Summer Limited Bag)
$19.50
Biore Sarasara UV Aqua Rich Watery Essence Sunscreen SPF50+ PA++++ 75g (2015 Spring Limited Bag)
$22.59
Biore Mens Nose Deep Cleansing Pore Pack Active Cool 10 Strips
$10.00
Shiseido Anessa Perfect UV Sunscreen EX SPF 50+ PA++++ 60ml
$26.71
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